Deoxyepinephrine

Deoxyepinephrine

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Structural formula of Deoxyepinephrine

Deoxyepinephrine, also known as 2-phenylethylamine, is a chemical compound that is structurally related to epinephrine, a hormone and neurotransmitter. Deoxyepinephrine is characterized by the absence of a hydroxyl group on the benzene ring, distinguishing it from its more well-known counterpart, epinephrine.

Chemical Structure

Deoxyepinephrine is a phenethylamine, a class of compounds that includes many biologically active substances. Its chemical structure consists of a benzene ring attached to an ethylamine chain. The absence of hydroxyl groups on the benzene ring differentiates it from epinephrine, which has hydroxyl groups at the 3 and 4 positions of the benzene ring.

Biological Activity

Deoxyepinephrine is not as biologically active as epinephrine. While epinephrine acts as a potent adrenergic receptor agonist, deoxyepinephrine lacks the necessary functional groups to effectively interact with these receptors. As a result, it does not exhibit the same physiological effects, such as increased heart rate and bronchodilation, that are characteristic of epinephrine.

Synthesis and Derivatives

Deoxyepinephrine can be synthesized through various chemical reactions involving the reduction of epinephrine or by direct synthesis from simpler precursors. It serves as a precursor or intermediate in the synthesis of other phenethylamine derivatives, some of which may have pharmacological activity.

Applications

While deoxyepinephrine itself is not widely used in medicine, its derivatives and related compounds are of interest in the development of new drugs. Researchers study these compounds to understand their potential effects on the central nervous system and their possible therapeutic applications.

Related Compounds

Deoxyepinephrine is related to several other compounds in the phenethylamine family, including:

• Epinephrine
• Norepinephrine
• Dopamine
• Amphetamine

These compounds share a common structural motif and are involved in various physiological processes.

Related Pages

• Epinephrine
• Adrenergic receptor
• Phenethylamine
• Neurotransmitter