Tienopramine

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Tienopramine is a chemical compound that belongs to the class of tricyclic antidepressants (TCAs). It is structurally related to other TCAs such as imipramine and amitriptyline. Tienopramine is primarily used in the treatment of depression and other mood disorders.

Chemical Structure and Properties

Tienopramine has a tricyclic structure, which consists of three interconnected rings. This structure is characteristic of the tricyclic antidepressant class. The chemical formula of tienopramine is C19H22N2S, and it has a molecular weight of 310.46 g/mol.

Mechanism of Action

As with other tricyclic antidepressants, tienopramine works by inhibiting the reuptake of neurotransmitters such as serotonin and norepinephrine in the brain. This leads to an increase in the levels of these neurotransmitters in the synaptic cleft, which helps alleviate symptoms of depression.

Pharmacokinetics

Tienopramine is absorbed from the gastrointestinal tract and undergoes extensive metabolism in the liver. The metabolites are excreted primarily through the kidneys. The half-life of tienopramine varies depending on individual metabolic rates and other factors.

Clinical Uses

Tienopramine is used in the treatment of:

• Major depressive disorder
• Anxiety disorders
• Chronic pain (off-label use)

Side Effects

Common side effects of tienopramine include:

• Dry mouth
• Constipation
• Urinary retention
• Blurred vision
• Drowsiness

Serious side effects may include:

• Cardiac arrhythmias
• Seizures
• Mania in patients with bipolar disorder

Contraindications

Tienopramine should not be used in patients with:

• Recent myocardial infarction
• Severe liver disease
• Narrow-angle glaucoma
• Known hypersensitivity to tricyclic antidepressants

Interactions

Tienopramine can interact with other medications, including:

• Monoamine oxidase inhibitors (MAOIs)
• Selective serotonin reuptake inhibitors (SSRIs)
• Anticholinergic drugs
• Antihypertensive medications

See Also

• Tricyclic antidepressant
• Imipramine
• Amitriptyline
• Depression (mood)
• Neurotransmitter