Tienopramine

Tienopramine is a tricyclic antidepressant (TCA) that was developed in the 1980s but was never marketed. It is structurally related to other tricyclic antidepressants such as imipramine and desipramine.

Pharmacology

Tienopramine acts by inhibiting the reuptake of both serotonin and norepinephrine, increasing the levels of these neurotransmitters in the brain. This action is thought to be responsible for the antidepressant effects of this and other tricyclic antidepressants.

Chemistry

Tienopramine is a tricyclic compound, meaning it contains three rings of atoms in its chemical structure. It is structurally similar to other tricyclic antidepressants, with the main difference being the substitution of a thienyl group in place of the usual phenyl group.

History

Tienopramine was developed in the 1980s as a potential new treatment for depression. Despite showing promise in early trials, it was never marketed, possibly due to the development of newer classes of antidepressants with fewer side effects, such as the selective serotonin reuptake inhibitors (SSRIs).

See also

• List of antidepressants
• List of withdrawn drugs