UH-232

UH-232‏‎ is a chemical compound that is often used in pharmacology and neuroscience research. It is a selective antagonist for the dopamine D2 and D3 receptors, which are primarily found in the brain.

History

UH-232 was first synthesized in the late 20th century as part of a series of compounds designed to study the effects of dopamine in the brain. It was developed by researchers at the University of Houston, which is how it got its name.

Pharmacology

UH-232 works by binding to the D2 and D3 dopamine receptors in the brain, preventing dopamine from activating these receptors. This can help to reduce the effects of conditions that are caused by excessive dopamine activity, such as schizophrenia and Parkinson's disease.

Uses

In research, UH-232 is often used as a tool to study the role of dopamine in the brain. It can be used in animal models to induce symptoms similar to those seen in schizophrenia and Parkinson's disease, allowing researchers to study these conditions in a controlled environment.

In medicine, UH-232 has potential as a treatment for conditions that are caused by excessive dopamine activity. However, it is not currently approved for use in humans.

Side Effects

As with any drug, UH-232 can have side effects. These can include nausea, vomiting, and dizziness. In animal studies, it has also been shown to cause changes in behavior, such as increased aggression and decreased social interaction.

See Also

• Dopamine
• Dopamine receptor
• Schizophrenia
• Parkinson's disease