Alpiropride

Overview of the drug Alpiropride

Alpiropride

Chemical structure of Alpiropride

Alpiropride is a pharmaceutical compound that belongs to the class of atypical antipsychotics. It is primarily used in the treatment of schizophrenia and other disorders characterized by psychosis. Alpiropride functions as a dopamine receptor antagonist, which helps in modulating the effects of dopamine in the brain, thereby alleviating symptoms of psychosis.

Pharmacology

Alpiropride acts on the central nervous system by selectively blocking dopamine D2 receptors. This action reduces the overactivity of dopamine pathways that are often implicated in psychotic disorders. Unlike typical antipsychotics, alpiropride has a lower affinity for serotonin receptors, which contributes to its atypical profile and potentially fewer side effects related to movement disorders.

Clinical Use

Alpiropride is indicated for the management of schizophrenia, particularly in patients who do not respond adequately to other antipsychotic medications. It may also be used off-label for other conditions as determined by a healthcare provider. The drug is administered orally, and the dosage is adjusted based on the patient's response and tolerance.

Side Effects

Common side effects of alpiropride include drowsiness, weight gain, and dry mouth. More serious side effects can include extrapyramidal symptoms, although these are less common compared to typical antipsychotics. Patients should be monitored for signs of tardive dyskinesia and neuroleptic malignant syndrome, which are rare but serious conditions associated with antipsychotic use.

Mechanism of Action

Alpiropride's primary mechanism involves the antagonism of dopamine D2 receptors in the brain. This action helps to balance the neurotransmitter activity, which is often disrupted in psychotic disorders. The drug's atypical nature is attributed to its selective receptor profile, which minimizes the risk of certain side effects commonly seen with older antipsychotic drugs.

History and Development

Alpiropride was developed as part of a new generation of antipsychotic medications aimed at improving the safety and efficacy profile compared to earlier treatments. Its development focused on reducing the incidence of side effects such as akathisia and dystonia, which are often associated with traditional antipsychotics.

Related pages

• Antipsychotic
• Schizophrenia
• Dopamine receptor antagonist
• Atypical antipsychotic