Muscarinic toxin 7
Muscarinic Toxin 7[edit | edit source]
Muscarinic Toxin 7 (MT7) is a peptide toxin derived from the venom of the African mamba snake, specifically the species Dendroaspis angusticeps. It is known for its high specificity and affinity for the muscarinic acetylcholine receptor subtype M1, making it a valuable tool in neuropharmacological research.
Structure[edit | edit source]
MT7 is a small protein composed of 65 amino acids. The three-dimensional structure of MT7, as determined by X-ray crystallography, reveals a compact fold stabilized by three disulfide bridges. This structure is crucial for its interaction with the M1 muscarinic receptor.
Mechanism of Action[edit | edit source]
Muscarinic Toxin 7 acts as a selective antagonist of the M1 muscarinic receptor. By binding to this receptor, MT7 inhibits the action of acetylcholine, a neurotransmitter involved in various central and peripheral nervous system functions. This inhibition can modulate neuronal excitability and synaptic transmission.
Applications in Research[edit | edit source]
Due to its specificity, MT7 is used extensively in research to study the physiological and pathological roles of the M1 receptor. It helps in understanding the receptor's involvement in cognitive processes, such as learning and memory, and its potential role in neurological disorders like Alzheimer's disease.
Related Toxins[edit | edit source]
MT7 is part of a family of muscarinic toxins found in mamba venom. Other members include Muscarinic Toxin 1 (MT1) and Muscarinic Toxin 3 (MT3), each with varying affinities for different muscarinic receptor subtypes.
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