Piperidolate

An anticholinergic drug used in the treatment of gastrointestinal disorders

Piperidolate
INN
Drug class
Routes of administration
Pregnancy category
Bioavailability
Metabolism
Elimination half-life
Excretion
Legal status
CAS Number
PubChem
DrugBank
ChemSpider
KEGG

Piperidolate is a pharmaceutical drug classified as an anticholinergic agent. It is primarily used in the treatment of gastrointestinal disorders such as irritable bowel syndrome and peptic ulcers. Piperidolate works by inhibiting the action of acetylcholine on muscarinic receptors, thereby reducing smooth muscle contractions and gastrointestinal motility.

Pharmacology

Piperidolate is an anticholinergic drug that exerts its effects by blocking the muscarinic acetylcholine receptors in the gastrointestinal tract. This action leads to a decrease in the tone and motility of the smooth muscles in the digestive system, providing relief from spasms and cramps.

Mechanism of Action

Chemical structure of Piperidolate

Piperidolate acts as a competitive antagonist at the muscarinic receptors. By preventing acetylcholine from binding to these receptors, it reduces the parasympathetic nervous system's influence on the gastrointestinal tract. This results in decreased secretions and muscle contractions, alleviating symptoms associated with hyperactive bowel conditions.

Clinical Uses

Piperidolate is indicated for the management of conditions such as:

• Irritable bowel syndrome (IBS)
• Peptic ulcer disease
• Gastrointestinal spasms

Side Effects

Common side effects of piperidolate include:

• Dry mouth
• Blurred vision
• Constipation
• Urinary retention

These side effects are typical of anticholinergic agents due to their action on the autonomic nervous system.

Contraindications

Piperidolate should not be used in individuals with:

• Glaucoma
• Myasthenia gravis
• Prostatic hypertrophy

Related pages

• Anticholinergic
• Muscarinic receptor
• Gastrointestinal tract