Pizotifen
An article about the medication Pizotifen
Overview[edit | edit source]
Pizotifen is a medication primarily used as a preventive treatment for migraine headaches. It is known for its ability to reduce the frequency and severity of migraine attacks. Pizotifen is also used in the management of cluster headaches.
Pharmacology[edit | edit source]
Pizotifen is classified as a serotonin antagonist and an antihistamine. It works by blocking certain serotonin receptors in the brain, which are thought to be involved in the development of migraines. Additionally, it has some anticholinergic properties.
Mechanism of Action[edit | edit source]
Pizotifen acts by inhibiting the action of serotonin, a neurotransmitter that can cause blood vessels in the brain to dilate, leading to migraine headaches. By blocking serotonin receptors, pizotifen helps to stabilize these blood vessels and prevent the onset of a migraine.
Clinical Use[edit | edit source]
Pizotifen is prescribed for the prevention of recurrent migraine attacks. It is not effective in treating an acute migraine attack once it has started. The medication is usually taken orally in the form of tablets.
Dosage and Administration[edit | edit source]
The typical starting dose of pizotifen is 0.5 mg taken once daily, usually at bedtime. The dose may be gradually increased based on the patient's response and tolerance, up to a maximum of 3 mg per day.
Side Effects[edit | edit source]
Common side effects of pizotifen include drowsiness, increased appetite, and weight gain. Some patients may experience dry mouth, dizziness, or nausea. It is important for patients to discuss any side effects with their healthcare provider.
Contraindications[edit | edit source]
Pizotifen should not be used in individuals with a known hypersensitivity to the drug. It is also contraindicated in patients with narrow-angle glaucoma or urinary retention.
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