Aceclidine
A parasympathomimetic agent used in ophthalmology
| Aceclidine | |
|---|---|
| |
| INN | |
| Drug class | |
| Routes of administration | Topical (eye drops) |
| Pregnancy category | |
| Bioavailability | |
| Metabolism | |
| Elimination half-life | |
| Excretion | |
| Legal status | Rx-only |
| CAS Number | 827-61-2 |
| PubChem | 1987 |
| DrugBank | DB13532 |
| ChemSpider | 1911 |
| KEGG | D02747 |
Aceclidine is a parasympathomimetic agent that is primarily used in the field of ophthalmology to treat glaucoma. It functions as a muscarinic acetylcholine receptor agonist, which leads to the contraction of the ciliary muscle and the sphincter muscle of the iris, resulting in miosis and a decrease in intraocular pressure.
Pharmacology[edit | edit source]
Aceclidine is a cholinergic drug that mimics the action of the neurotransmitter acetylcholine. It specifically targets the muscarinic receptors in the eye, leading to increased outflow of aqueous humor and reduced intraocular pressure. This makes it effective in the management of open-angle glaucoma and ocular hypertension.
Mechanism of Action[edit | edit source]
Aceclidine acts by stimulating the muscarinic receptors in the eye, which are part of the parasympathetic nervous system. This stimulation causes the ciliary muscle to contract, opening the trabecular meshwork and facilitating the drainage of aqueous humor from the anterior chamber of the eye. The contraction of the sphincter muscle of the iris also results in miosis, which can help in reducing intraocular pressure.
Clinical Use[edit | edit source]
Aceclidine is administered as eye drops for the treatment of glaucoma and ocular hypertension. It is particularly useful in patients who are intolerant to other antiglaucoma medications or in combination with other drugs to achieve better control of intraocular pressure.
Side Effects[edit | edit source]
Common side effects of aceclidine include eye irritation, blurred vision, and headache. Due to its action on the parasympathetic nervous system, it may also cause systemic effects such as sweating, salivation, and nausea if absorbed in significant amounts.
Related pages[edit | edit source]
Gallery[edit | edit source]
Chemical structure of Aceclidine
3D ball-and-stick model of Aceclidine
Aceclidine.svg
Aceclidine 3D ball
Search WikiMD
Ad.Tired of being Overweight? Try W8MD's physician weight loss program.
Semaglutide (Ozempic / Wegovy and Tirzepatide (Mounjaro / Zepbound) available.
Advertise on WikiMD
|
WikiMD's Wellness Encyclopedia |
| Let Food Be Thy Medicine Medicine Thy Food - Hippocrates |
Translate this page: - East Asian
中文,
日本,
한국어,
South Asian
हिन्दी,
தமிழ்,
తెలుగు,
Urdu,
ಕನ್ನಡ,
Southeast Asian
Indonesian,
Vietnamese,
Thai,
မြန်မာဘာသာ,
বাংলা
European
español,
Deutsch,
français,
Greek,
português do Brasil,
polski,
română,
русский,
Nederlands,
norsk,
svenska,
suomi,
Italian
Middle Eastern & African
عربى,
Turkish,
Persian,
Hebrew,
Afrikaans,
isiZulu,
Kiswahili,
Other
Bulgarian,
Hungarian,
Czech,
Swedish,
മലയാളം,
मराठी,
ਪੰਜਾਬੀ,
ગુજરાતી,
Portuguese,
Ukrainian
Medical Disclaimer: WikiMD is not a substitute for professional medical advice. The information on WikiMD is provided as an information resource only, may be incorrect, outdated or misleading, and is not to be used or relied on for any diagnostic or treatment purposes. Please consult your health care provider before making any healthcare decisions or for guidance about a specific medical condition. WikiMD expressly disclaims responsibility, and shall have no liability, for any damages, loss, injury, or liability whatsoever suffered as a result of your reliance on the information contained in this site. By visiting this site you agree to the foregoing terms and conditions, which may from time to time be changed or supplemented by WikiMD. If you do not agree to the foregoing terms and conditions, you should not enter or use this site. See full disclaimer.
Credits:Most images are courtesy of Wikimedia commons, and templates, categories Wikipedia, licensed under CC BY SA or similar.
Contributors: Prab R. Tumpati, MD
