Aceclidine

Aceclidine is a parasympathomimetic agent used in the treatment of glaucoma. It is a cholinergic agonist that works by increasing the outflow of aqueous humor from the eye, which lowers intraocular pressure.

Mechanism of Action

Aceclidine acts as a direct cholinergic agonist at muscarinic acetylcholine receptors. It mimics the action of acetylcholine at the muscarinic receptors, leading to an increase in the outflow of aqueous humor from the eye. This results in a decrease in intraocular pressure, which is beneficial in the treatment of glaucoma.

Uses

Aceclidine is primarily used in the treatment of glaucoma. It can be used in both open-angle glaucoma and closed-angle glaucoma. It is also used in the treatment of xerostomia (dry mouth) and Sjögren's syndrome, a condition that causes dry eyes and mouth.

Side Effects

Common side effects of aceclidine include blurred vision, eye pain, and headache. Less common side effects include nausea, vomiting, diarrhea, abdominal pain, and sweating. Rare but serious side effects include allergic reactions, bronchospasm, and cardiac arrhythmias.

Contraindications

Aceclidine is contraindicated in individuals with a known hypersensitivity to the drug. It is also contraindicated in individuals with asthma, coronary artery disease, peptic ulcer disease, and Parkinson's disease due to the potential for exacerbation of these conditions.

See Also

• Parasympathomimetic
• Glaucoma
• Cholinergic
• Agonist
• Aqueous humor
• Intraocular pressure
• Xerostomia
• Sjögren's syndrome
• Muscarinic acetylcholine receptor

Aceclidine Resources
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