Parasympathomimetic

Parasympathomimetic drugs, also known as cholinergic drugs, are a type of medication that produce effects similar to those of the parasympathetic nervous system. They are used to treat a variety of conditions, including glaucoma, Alzheimer's disease, and myasthenia gravis.

Mechanism of Action

Parasympathomimetic drugs work by mimicking the effects of the neurotransmitter acetylcholine. They can either directly stimulate the muscarinic receptor or they can inhibit the enzyme acetylcholinesterase, which breaks down acetylcholine in the synaptic cleft. This results in an increase in parasympathetic activity.

Uses

Parasympathomimetic drugs are used in the treatment of a variety of conditions. These include:

• Glaucoma: These drugs can decrease intraocular pressure by increasing the outflow of aqueous humor.
• Alzheimer's disease: Some parasympathomimetic drugs can slow the progression of Alzheimer's disease by increasing the levels of acetylcholine in the brain.
• Myasthenia gravis: These drugs can improve muscle strength by increasing the amount of acetylcholine at the neuromuscular junction.

Side Effects

Like all medications, parasympathomimetic drugs can cause side effects. These may include:

• Nausea and vomiting
• Diarrhea
• Bronchospasm
• Bradycardia
• Hypotension

See Also

• Parasympatholytic
• Sympathomimetic drug
• Sympatholytic

Parasympathomimetic Resources
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