Imipraminoxide

What is Imipraminoxide?

Imipraminoxide or imipramine N-oxide, is a tricyclic antidepressant (TCA).

Uses

It was introduced in Europe in the 1960s for the treatment of depression.

Mechanism of action

likely acts as a serotonin and norepinephrine reuptake inhibitor and serotonin, adrenaline, histamine, and muscarinic acetylcholine receptor antagonist, though with weaker antiadrenergic and anticholinergic actions

Side effects

Imipraminoxide is both an analogue and a metabolite of imipramine, and has similar effects.

Comparison to Imipramine

In clinical trials, imipraminoxide, when compared to imipramine, was found to have the following benefits:

• faster onset of action,
• slightly higher efficacy, and
• fewer and less marked side effects, including
• * diminished orthostatic hypotension and
• * anticholinergic effects like dry mouth, sweating, dizziness, and fatigue

Pharmacology

Imipraminoxide's pharmacology has not been well elucidated.

Brand names

Brand names include:

1. Imiprex,
2. Elepsin

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The following are antidepressant subclasses and drugs

MAO Inhibitors Isocarboxazid, Phenelzine, Tranylcypromine

SNRIs Duloxetine, Levomilnacipran, Venlafaxine

SSRIs Citalopram, Escitalopram, Fluoxetine, Fluvoxamine, Paroxetine, Sertraline, Vilazodone, Vortioxetine

Tricyclics Amitriptyline, Amoxapine, Clomipramine, Desipramine, Doxepin, Imipramine, Nortriptyline, Protriptyline, Trimipramine

Miscellaneous Bupropion, Flibanserin, Mirtazapine, Nefazodone, Trazodone