Imipraminoxide
What is Imipraminoxide?[edit | edit source]
Imipraminoxide or imipramine N-oxide, is a tricyclic antidepressant (TCA).
Uses[edit | edit source]
It was introduced in Europe in the 1960s for the treatment of depression.
Mechanism of action[edit | edit source]
likely acts as a serotonin and norepinephrine reuptake inhibitor and serotonin, adrenaline, histamine, and muscarinic acetylcholine receptor antagonist, though with weaker antiadrenergic and anticholinergic actions
Side effects[edit | edit source]
Imipraminoxide is both an analogue and a metabolite of imipramine, and has similar effects.
Comparison to Imipramine[edit | edit source]
In clinical trials, imipraminoxide, when compared to imipramine, was found to have the following benefits:
- faster onset of action,
- slightly higher efficacy, and
- fewer and less marked side effects, including
- * diminished orthostatic hypotension and
- * anticholinergic effects like dry mouth, sweating, dizziness, and fatigue
Pharmacology[edit | edit source]
Imipraminoxide's pharmacology has not been well elucidated.
Brand names[edit | edit source]
Brand names include:
- Imiprex,
- Elepsin
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The following are antidepressant subclasses and drugs
MAO Inhibitors Isocarboxazid, Phenelzine, Tranylcypromine
SNRIs Duloxetine, Levomilnacipran, Venlafaxine
SSRIs Citalopram, Escitalopram, Fluoxetine, Fluvoxamine, Paroxetine, Sertraline, Vilazodone, Vortioxetine
Tricyclics Amitriptyline, Amoxapine, Clomipramine, Desipramine, Doxepin, Imipramine, Nortriptyline, Protriptyline, Trimipramine
Miscellaneous Bupropion, Flibanserin, Mirtazapine, Nefazodone, Trazodone
| Tricyclics | ||||||||||
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