Amineptine

Amineptine

Amineptine, sold under the brand name Survector among others, is an atypical antidepressant that is no longer marketed. It was developed by the French Society of Medical Research in the 1960s.

Pharmacology

Amineptine is a tricyclic antidepressant (TCA) that selectively inhibits the reuptake of dopamine and to a lesser extent, norepinephrine, thereby increasing the levels of these neurotransmitters in the brain. Unlike other TCAs, it does not inhibit the reuptake of serotonin and does not have anticholinergic properties.

Medical uses

Amineptine was used for the treatment of major depressive disorder and dysthymia. It was noted for its activating and stimulant effects, making it useful for patients with retarded depression.

Side effects

Common side effects of amineptine include insomnia, agitation, irritability, hypomania and skin rash. Rare but serious side effects include hepatotoxicity and dependence.

History

Amineptine was developed by the French Society of Medical Research in the 1960s. It was withdrawn from the market in the late 1990s due to concerns about its potential for abuse and hepatotoxicity.

Society and culture

Amineptine was marketed under several brand names, including Survector, Maneon, Directim, and Neolior. It was available in some countries in Europe, South America, and Asia, but was never approved for use in the United States.

See also

• List of antidepressants
• List of withdrawn drugs