Indanidine
Indanidine is a vasodilator and antihypertensive drug. It is a selective alpha-2 adrenergic receptor agonist that is used to treat hypertension.
Mechanism of action[edit | edit source]
Indanidine works by stimulating alpha-2 adrenergic receptors in the brain, which decreases sympathetic nervous system activity and reduces blood pressure. It also has a direct relaxing effect on vascular smooth muscle.
Uses[edit | edit source]
Indanidine is used to treat hypertension. It may be used alone or in combination with other antihypertensive drugs.
Side effects[edit | edit source]
Common side effects of indanidine include dizziness, fatigue, and dry mouth. Less common side effects include depression, sleep disturbances, and sexual dysfunction.
Contraindications[edit | edit source]
Indanidine is contraindicated in patients with severe bradycardia, heart block, or heart failure. It should also be used with caution in patients with a history of depression or other psychiatric disorders.
Interactions[edit | edit source]
Indanidine may interact with other drugs, including other antihypertensive drugs, antidepressants, and sedatives. It may also interact with alcohol, increasing the risk of dizziness and fainting.
Pharmacokinetics[edit | edit source]
Indanidine is rapidly absorbed after oral administration and has a half-life of about 12 hours. It is metabolized in the liver and excreted in the urine.
See also[edit | edit source]
| Indanidine Resources | |
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