Indanidine

Indanidine is a vasodilator and antihypertensive drug. It is a selective alpha-2 adrenergic receptor agonist that is used to treat hypertension.

Mechanism of action[edit | edit source]

Indanidine works by stimulating alpha-2 adrenergic receptors in the brain, which decreases sympathetic nervous system activity and reduces blood pressure. It also has a direct relaxing effect on vascular smooth muscle.

Uses[edit | edit source]

Indanidine is used to treat hypertension. It may be used alone or in combination with other antihypertensive drugs.

Side effects[edit | edit source]

Common side effects of indanidine include dizziness, fatigue, and dry mouth. Less common side effects include depression, sleep disturbances, and sexual dysfunction.

Contraindications[edit | edit source]

Indanidine is contraindicated in patients with severe bradycardia, heart block, or heart failure. It should also be used with caution in patients with a history of depression or other psychiatric disorders.

Interactions[edit | edit source]

Indanidine may interact with other drugs, including other antihypertensive drugs, antidepressants, and sedatives. It may also interact with alcohol, increasing the risk of dizziness and fainting.

Pharmacokinetics[edit | edit source]

Indanidine is rapidly absorbed after oral administration and has a half-life of about 12 hours. It is metabolized in the liver and excreted in the urine.

See also[edit | edit source]

Indanidine Resources
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