File:Mirtazapine.svg Mirtazapine structure File:Mirtazapine-from-xtal-2003-US-patent-6723845-3D-balls.png Mirtazapine 3-D balls Mirtazapine is a tetracyclic antidepressant with a somewhat unique mechanism of action.
Liver safety of Mirtazapine [ edit ] Mirtazapine therapy can be associated with transient asymptomatic elevations in serum aminotransferase levels and has been linked to rare instances of clinically apparent acute liver injury.
Mechanism of action of Mirtazapine [ edit ] Mirtazapine (mir taz' a peen) is a tetracyclic derivative with a somewhat unique antidepressant activity in comparison to the selective serotonin reuptake inhibitors (SSRIs) and tricyclic antidepressants. Its mechanism of action is not well defined, but it is a potent antagonist of serotonin 5-HT2 and 5-HT3 receptors and appears to enhance central noradrenergic and serotonergic (5-HT1A) activity with less activity against peripheral receptors.
FDA approval information for Mirtazapine [ edit ] Mirtazapine was approved for use in moderate and severe depression in the United States in 1996 and remains in wide use, with more than 5 million prescriptions being filled yearly.
Brand name for Mirtazapine [ edit ] The major indication for mirtazapine therapy is major depressive disorder. Mirtazapine is available as regular and oral disintegrating tablets of 15, 30 and 45 mg in multiple generic forms and under the brand name Remeron .
Dosage and administration for Mirtazapine [ edit ] The recommended dosage in adults is 15 mg once daily at bedtime, which can be increased to a maximum of 45 mg daily.
Side effects of Mirtazapine [ edit ] Common side effects are drowsiness , fatigue, blurred vision, dry mouth , increased appetite and weight gain .
Medical uses
Template:Anxiolytics
Hypnotics and Sedatives
ATC Code: N05C
Insomnia pharmacotherapies
GABAA R
PAMs
*
Benzodiazepines :Brotizolam
Cinolazepam Climazolam Clorazepate Doxefazepam Estazolam Etizolam Flunitrazepam Flurazepam Flutoprazepam Haloxazolam Loprazolam Lormetazepam Midazolam Nimetazepam Nitrazepam Quazepam Temazepam Triazolam ; Nonbenzodiazepines /Z-drugs :Eszopiclone Zaleplon Zolpidem Zopiclone ; Others: Alcohols (e.g., ethchlorvynol , amylene hydrate , ethanol )Barbiturates (e.g., amobarbital , pentobarbital , phenobarbital , secobarbital )Bromides (e.g., potassium bromide , sodium bromide )Carbamates (e.g., meprobamate )Chloral hydrate Clomethiazole Kava Paraldehyde Piperidinediones (e.g., glutethimide )Quinazolinones (e.g., methaqualone )Sulfonmethane Valerian
Antihistamines (H1 R
inverse agonists )
OXR
antagonists
MTR
agonists
Miscellaneous
Pharmacodynamics
Adrenergic receptor modulators
α1
Agonists
Antagonists *
Abanoquil
Ajmalicine Alfuzosin Anisodamine Anisodine Atiprosin Atypical antipsychotics (e.g., brexpiprazole , clozapine , olanzapine , quetiapine , risperidone )Benoxathian Beta blockers (e.g., adimolol , amosulalol , arotinolol , carvedilol , eugenodilol , labetalol )Buflomedil Bunazosin Corynanthine Dapiprazole Domesticine Doxazosin Ergolines (e.g., acetergamine , ergotamine , dihydroergotamine , lisuride , nicergoline , terguride )Etoperidone Fenspiride Hydroxyzine Indoramin Ketanserin L-765,314 mCPP Mepiprazole Metazosin Monatepil Moxisylyte Naftopidil Nantenine Neldazosin Niaprazine Niguldipine Pardoprunox Pelanserin Perlapine Phendioxan Phenoxybenzamine Phentolamine Phenylpiperazine antidepressants (e.g., hydroxynefazodone , nefazodone , trazodone , triazoledione )Piperoxan Prazosin Quinazosin Quinidine Silodosin Spegatrine Spiperone Talipexole Tamsulosin Terazosin Tiodazosin Tolazoline Tetracyclic antidepressants (e.g., amoxapine , maprotiline , mianserin )Tricyclic antidepressants (e.g., amitriptyline , clomipramine , doxepin , imipramine , trimipramine )Trimazosin Typical antipsychotics (e.g., chlorpromazine , fluphenazine , loxapine , thioridazine )Urapidil WB-4101 Zolertine
α2
Agonists
Antagonists *
1-PP
Adimolol Amesergide Aptazapine Atipamezole Atypical antipsychotics (e.g., asenapine , brexpiprazole , clozapine , lurasidone , olanzapine , paliperidone , quetiapine , risperidone , zotepine )Azapirones (e.g., buspirone , gepirone , ipsapirone , tandospirone )BRL-44408 Buflomedil Cirazoline Efaroxan Esmirtazapine Fenmetozole Fluparoxan Idazoxan Ketanserin Lisuride mCPP Mianserin Mirtazapine NAN-190 Pardoprunox Phentolamine Phenoxybenzamine Piperoxan Piribedil Rauwolscine Rotigotine Setiptiline Spegatrine Spiroxatrine Sunepitron Terguride Tolazoline Typical antipsychotics (e.g., chlorpromazine , fluphenazine , loxapine , thioridazine )Yohimbine
β
Histamine receptor modulators
H1 *
Agonists: 2-Pyridylethylamine
Others: Atypical antipsychotics (e.g., aripiprazole , asenapine , brexpiprazole , brilaroxazine , clozapine , iloperidone , olanzapine , paliperidone , quetiapine , risperidone , ziprasidone , zotepine )Phenylpiperazine antidepressants (e.g., hydroxynefazodone , nefazodone , trazodone , triazoledione )Tetracyclic antidepressants (e.g., amoxapine , loxapine , maprotiline , mianserin , mirtazapine , oxaprotiline )Tricyclic antidepressants (e.g., amitriptyline , butriptyline , clomipramine , desipramine , dosulepin (dothiepin) , doxepin , imipramine , iprindole , lofepramine , nortriptyline , protriptyline , trimipramine )Typical antipsychotics (e.g., chlorpromazine , flupenthixol , fluphenazine , loxapine , perphenazine , prochlorperazine , thioridazine , thiothixene )
H2
H3
H4
