Pirbuterol

Pirbuterol

Pirbuterol is a bronchodilator that is used in the treatment of asthma and chronic obstructive pulmonary disease (COPD). It belongs to the class of medications known as beta-2 adrenergic agonists, which work by relaxing and opening the air passages to the lungs to make breathing easier.

Pharmacology

Pirbuterol acts on the beta-2 adrenergic receptor, leading to smooth muscle relaxation in the bronchial tubes and vasculature of the lungs. This results in bronchodilation and increased airflow. The drug is administered via inhalation, allowing for direct action on the bronchial smooth muscle with minimal systemic effects.

Clinical Use

Pirbuterol is primarily used in the management of asthma and COPD. It is used as a rescue medication to treat acute episodes of bronchospasm. It can also be used as a preventive measure before exposure to triggers such as exercise or allergens.

Side Effects

Common side effects of pirbuterol include palpitations, tremors, nervousness, and headache. Less common side effects may include hypokalemia, hyperglycemia, and tachycardia. As with all beta-2 adrenergic agonists, there is a risk of paradoxical bronchospasm, which is a worsening of breathing problems after use of the medication.

Contraindications

Pirbuterol is contraindicated in patients with a history of hypersensitivity to the drug or any of its components. It should be used with caution in patients with cardiovascular disorders, especially coronary insufficiency, cardiac arrhythmias, and hypertension.

See Also

• Beta-2 adrenergic agonist
• Bronchodilator
• Asthma
• Chronic obstructive pulmonary disease

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