Diphenylpyraline

Antihistamine medication

Diphenylpyraline
INN
Drug class
Routes of administration
Pregnancy category
Bioavailability
Metabolism
Elimination half-life
Excretion
Legal status
CAS Number
PubChem
DrugBank
ChemSpider
KEGG

Diphenylpyraline is a first-generation antihistamine with anticholinergic properties. It is primarily used to treat allergic rhinitis and other allergic conditions.

Pharmacology

Diphenylpyraline works by blocking the action of histamine at the H1 receptor, which helps to reduce the symptoms of allergic reactions such as sneezing, itching, and runny nose. As a first-generation antihistamine, it can cross the blood-brain barrier, leading to sedation and drowsiness as common side effects.

Chemical Structure

Diphenylpyraline structure

Diphenylpyraline is chemically classified as a piperidine derivative. Its structure consists of a piperidine ring with two phenyl groups attached, which is characteristic of many antihistamines in this class.

Synthesis

Diphenylpyraline synthesis

The synthesis of diphenylpyraline involves the reaction of 4-benzhydrylpiperidine with appropriate reagents to form the final product. This process is typical for the production of piperidine-based antihistamines.

Medical Uses

Diphenylpyraline is used to alleviate symptoms associated with allergic reactions, such as hay fever, urticaria, and allergic conjunctivitis. It is also sometimes used in the treatment of common cold symptoms due to its ability to reduce nasal congestion and other related symptoms.

Side Effects

Common side effects of diphenylpyraline include drowsiness, dry mouth, blurred vision, and urinary retention. These effects are due to its anticholinergic activity. Patients are advised to avoid operating heavy machinery or driving while taking this medication.

Related Pages

• Antihistamine
• Allergic rhinitis
• Piperidine