Atipamezole
Atipamezole is a synthetic alpha2-adrenergic receptor antagonist, with a high selectivity towards alpha2-adrenergic receptors versus alpha1-adrenergic receptors. It is used in veterinary medicine to reverse the sedative and analgesic effects of medetomidine and dexmedetomidine in dogs, cats, and other animals.
Pharmacology[edit | edit source]
Atipamezole works by blocking the alpha2-adrenergic receptors in the central nervous system. This results in an increase in sympathetic tone, which can reverse the effects of alpha2-adrenergic agonists like medetomidine and dexmedetomidine.
Uses[edit | edit source]
Atipamezole is primarily used in veterinary medicine to reverse the sedative and analgesic effects of medetomidine and dexmedetomidine. It is administered intramuscularly or subcutaneously, and its effects can be seen within a few minutes of administration.
Side Effects[edit | edit source]
Possible side effects of atipamezole include vomiting, diarrhea, salivation, and tremors. These side effects are usually mild and transient.
See Also[edit | edit source]
References[edit | edit source]
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