Tienoxolol

An article about the beta-blocker Tienoxolol

Tienoxolol

Tienoxolol is a beta-adrenergic receptor antagonist (beta-blocker) used in the management of hypertension and other cardiovascular conditions. It is known for its selective action on beta-1 adrenergic receptors, which are primarily located in the heart.

Pharmacology

Mechanism of Action

Tienoxolol works by blocking the beta-1 adrenergic receptors in the heart, leading to a decrease in heart rate and cardiac output. This action reduces the workload on the heart and lowers blood pressure. Unlike non-selective beta-blockers, Tienoxolol has minimal effects on beta-2 receptors, which are found in the lungs and vascular smooth muscle.

Pharmacokinetics

Tienoxolol is administered orally and is well absorbed from the gastrointestinal tract. It undergoes hepatic metabolism and is excreted primarily in the urine. The drug has a half-life that allows for once-daily dosing, which can improve patient compliance.

Clinical Uses

Tienoxolol is primarily used in the treatment of hypertension. It may also be used in the management of angina pectoris and in the prevention of myocardial infarction.

Side Effects

Common side effects of Tienoxolol include bradycardia, fatigue, and dizziness. As with other beta-blockers, it may cause or exacerbate bronchospasm in susceptible individuals, such as those with asthma.

Contraindications

Tienoxolol is contraindicated in patients with bradycardia, heart block, and cardiogenic shock. Caution is advised in patients with diabetes mellitus and chronic obstructive pulmonary disease (COPD).

Related pages

• Beta blocker
• Hypertension
• Cardiovascular disease