Tetracyclic antidepressant
Overview of tetracyclic antidepressants
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Tetracyclic Antidepressants[edit | edit source]
Tetracyclic antidepressants (TeCAs) are a class of antidepressant drugs that are chemically distinct from the more common tricyclic antidepressants (TCAs). They are named for their four-ring chemical structure. TeCAs are primarily used in the treatment of major depressive disorder and other mood disorders.
Mechanism of Action[edit | edit source]
TeCAs work by modulating the levels of neurotransmitters in the brain, particularly serotonin and norepinephrine. They are known to block certain receptors, such as the alpha-2 adrenergic receptor, which leads to an increase in the release of norepinephrine and serotonin. This action is thought to contribute to their antidepressant effects.
Common Tetracyclic Antidepressants[edit | edit source]
One of the most well-known tetracyclic antidepressants is mirtazapine. Mirtazapine is often used for its sedative properties and is sometimes prescribed to patients who have difficulty sleeping. It is also known for having a lower incidence of sexual side effects compared to other antidepressants.
Side Effects[edit | edit source]
TeCAs can cause a range of side effects, which may include weight gain, sedation, and dry mouth. Some patients may experience dizziness or orthostatic hypotension. It is important for patients to discuss potential side effects with their healthcare provider.
Comparison with Other Antidepressants[edit | edit source]
TeCAs are less commonly prescribed than selective serotonin reuptake inhibitors (SSRIs) and serotonin-norepinephrine reuptake inhibitors (SNRIs) due to their side effect profile. However, they may be beneficial for patients who do not respond to other treatments or who have specific symptoms that TeCAs can address.
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