Primidolol
Primidolol[edit | edit source]
Primidolol is a beta-adrenergic receptor antagonist (beta-blocker) that is used in the management of various cardiovascular conditions. It is a non-selective beta-blocker, meaning it inhibits both beta-1 and beta-2 adrenergic receptors. This medication is primarily used to treat hypertension, angina pectoris, and certain types of arrhythmias.
Mechanism of Action[edit | edit source]
Primidolol works by blocking the effects of epinephrine (adrenaline) and norepinephrine on beta-adrenergic receptors. By inhibiting these receptors, primidolol reduces the heart rate, decreases cardiac output, and lowers blood pressure. This action helps to alleviate the symptoms of angina and prevent arrhythmias by reducing the workload on the heart.
Pharmacokinetics[edit | edit source]
Primidolol is administered orally and is absorbed through the gastrointestinal tract. It undergoes hepatic metabolism and is excreted primarily through the kidneys. The half-life of primidolol allows for dosing once or twice daily, depending on the clinical scenario and patient response.
Clinical Uses[edit | edit source]
Primidolol is indicated for the treatment of:
- Hypertension: By lowering blood pressure, primidolol helps to reduce the risk of stroke and myocardial infarction.
- Angina pectoris: It decreases the frequency and severity of angina attacks by reducing myocardial oxygen demand.
- Arrhythmias: It is used in the management of certain types of arrhythmias by stabilizing cardiac electrical activity.
Side Effects[edit | edit source]
Common side effects of primidolol include:
- Bradycardia (slow heart rate)
- Hypotension (low blood pressure)
- Fatigue
- Dizziness
- Gastrointestinal disturbances
Less common but serious side effects may include:
- Bronchospasm, especially in patients with asthma or COPD
- Heart failure
- Depression
Contraindications[edit | edit source]
Primidolol should not be used in patients with:
- Asthma or severe chronic obstructive pulmonary disease (COPD)
- Bradycardia
- Heart block
- Cardiogenic shock
Related Pages[edit | edit source]
Search WikiMD
Ad.Tired of being Overweight? Try W8MD's physician weight loss program.
Semaglutide (Ozempic / Wegovy and Tirzepatide (Mounjaro / Zepbound) available.
Advertise on WikiMD
|
WikiMD's Wellness Encyclopedia |
| Let Food Be Thy Medicine Medicine Thy Food - Hippocrates |
Translate this page: - East Asian
中文,
日本,
한국어,
South Asian
हिन्दी,
தமிழ்,
తెలుగు,
Urdu,
ಕನ್ನಡ,
Southeast Asian
Indonesian,
Vietnamese,
Thai,
မြန်မာဘာသာ,
বাংলা
European
español,
Deutsch,
français,
Greek,
português do Brasil,
polski,
română,
русский,
Nederlands,
norsk,
svenska,
suomi,
Italian
Middle Eastern & African
عربى,
Turkish,
Persian,
Hebrew,
Afrikaans,
isiZulu,
Kiswahili,
Other
Bulgarian,
Hungarian,
Czech,
Swedish,
മലയാളം,
मराठी,
ਪੰਜਾਬੀ,
ગુજરાતી,
Portuguese,
Ukrainian
Medical Disclaimer: WikiMD is not a substitute for professional medical advice. The information on WikiMD is provided as an information resource only, may be incorrect, outdated or misleading, and is not to be used or relied on for any diagnostic or treatment purposes. Please consult your health care provider before making any healthcare decisions or for guidance about a specific medical condition. WikiMD expressly disclaims responsibility, and shall have no liability, for any damages, loss, injury, or liability whatsoever suffered as a result of your reliance on the information contained in this site. By visiting this site you agree to the foregoing terms and conditions, which may from time to time be changed or supplemented by WikiMD. If you do not agree to the foregoing terms and conditions, you should not enter or use this site. See full disclaimer.
Credits:Most images are courtesy of Wikimedia commons, and templates, categories Wikipedia, licensed under CC BY SA or similar.
Contributors: Prab R. Tumpati, MD
