Oxyprothepin
Oxyprothepin is a tricyclic antidepressant (TCA) that was used in the United Kingdom for the treatment of depression but is now no longer marketed. It is a potent and selective H1 receptor antagonist with weak anticholinergic and antiserotonergic effects and no significant alpha-1 blocking effects.
Pharmacology[edit | edit source]
Oxyprothepin acts by inhibiting the reuptake of norepinephrine and serotonin, thereby increasing the levels of these neurotransmitters in the brain. It also has a high affinity for the H1 receptor, which is responsible for its sedative effects.
Side effects[edit | edit source]
The side effects of oxyprothepin are similar to those of other tricyclic antidepressants. They include dry mouth, blurred vision, constipation, urinary retention, orthostatic hypotension, tachycardia, and weight gain. In rare cases, it can cause cardiac arrhythmia and seizures.
Interactions[edit | edit source]
Oxyprothepin can interact with other medications, including other antidepressants, antipsychotics, antihistamines, and anticholinergics. It can also interact with alcohol, increasing the risk of sedation and respiratory depression.
See also[edit | edit source]
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