Oxyprothepin decanoate

Oxyprothepin decanoate

Oxyprothepin decanoate is a typical antipsychotic drug of the dibenzothiepin chemical class. It is used in the treatment of schizophrenia and other forms of psychosis. It is a long-acting decanoate ester prodrug of oxyprothepin that is administered by intramuscular injection.

Pharmacology

Oxyprothepin decanoate acts primarily as a dopamine antagonist, blocking the D2 receptor. This action is believed to be responsible for the drug's antipsychotic effects. It also has anticholinergic, antihistamine, and antiadrenergic properties, which contribute to its side effect profile.

Clinical Use

Oxyprothepin decanoate is used in the management of schizophrenia and other psychotic disorders. It is particularly useful in patients who have difficulty adhering to a regular medication schedule, as the long-acting formulation allows for less frequent dosing.

Side Effects

Common side effects of oxyprothepin decanoate include dry mouth, blurred vision, constipation, and urinary retention. These are largely due to the drug's anticholinergic effects. It can also cause sedation, weight gain, and orthostatic hypotension. Rare but serious side effects include tardive dyskinesia, neuroleptic malignant syndrome, and agranulocytosis.

See Also

• List of antipsychotic drugs
• Schizophrenia
• Psychosis