D2 receptor

D2 receptor is a protein that is encoded by the DRD2 gene in humans. It is a member of the dopamine receptor subgroup of the G protein-coupled receptor superfamily. The D2 receptor is the main receptor for most antipsychotic drugs.

Function

The D2 receptor is a crucial component in the dopamine system, which plays a significant role in reward, pleasure, and addiction. It also plays a role in the regulation of movement and emotional responses. The D2 receptor has two different isoforms: D2L and D2S, which have different functions and are expressed in different areas of the brain.

Clinical significance

Alterations in the function or expression of the D2 receptor have been associated with various psychiatric and neurological disorders, including schizophrenia, Parkinson's disease, and drug addiction. Antipsychotic drugs, which are often used to treat schizophrenia, primarily work by blocking the D2 receptor.

Pharmacology

The D2 receptor is the target of many antipsychotic drugs, including haloperidol, risperidone, and olanzapine. These drugs work by blocking the D2 receptor, thereby reducing the effects of dopamine in the brain.

See also

• Dopamine receptor
• D1 receptor
• D3 receptor
• D4 receptor
• D5 receptor

External links

• D2 receptor at the IUPHAR Database
• Human DRD2 genome location and DRD2 gene details page in the UCSC Genome Browser.

D2 receptor Resources
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