Nicergoline
Nicergoline (sold under the brand name Sermion among others) is an ergot derivative used to treat senile dementia and other disorders with vascular origins. It has been used internationally for frontotemporal dementia, as well as early onset in Lewy body dementia and Parkinson's disease dementia.
Mechanism of action[edit | edit source]
Nicergoline decreases vascular resistance and increases arterial blood flow in the brain, improving the utilization of oxygen and glucose by brain cells. It has similar vasoactive properties in other areas of the body, particularly the lungs.
Safety profile[edit | edit source]
Unlike many other ergolines, such as ergotamine, nicergoline is not associated with cardiac fibrosis.
Indications and usage[edit | edit source]
Nicergoline is primarily used for the treatment of:
- Senile dementia
- Vascular disorders, including ischemic stroke
- Frontotemporal dementia
- Early onset in Lewy body dementia
- Parkinson's disease dementia
Contraindications[edit | edit source]
Nicergoline is contraindicated in patients with a known hypersensitivity to the drug or other ergot derivatives.
Side effects[edit | edit source]
Side effects of nicergoline may include:
- Dizziness
- Nausea
- Headache
- Hypotension
- Gastrointestinal discomfort
See also[edit | edit source]
| Nicergoline Resources | |
|---|---|
|
 |
Search WikiMD
Ad.Tired of being Overweight? Try W8MD's physician weight loss program.
Semaglutide (Ozempic / Wegovy and Tirzepatide (Mounjaro / Zepbound) available.
Advertise on WikiMD
|
WikiMD's Wellness Encyclopedia |
| Let Food Be Thy Medicine Medicine Thy Food - Hippocrates |
Translate this page: - East Asian
中文,
日本,
한국어,
South Asian
हिन्दी,
தமிழ்,
తెలుగు,
Urdu,
ಕನ್ನಡ,
Southeast Asian
Indonesian,
Vietnamese,
Thai,
မြန်မာဘာသာ,
বাংলা
European
español,
Deutsch,
français,
Greek,
português do Brasil,
polski,
română,
русский,
Nederlands,
norsk,
svenska,
suomi,
Italian
Middle Eastern & African
عربى,
Turkish,
Persian,
Hebrew,
Afrikaans,
isiZulu,
Kiswahili,
Other
Bulgarian,
Hungarian,
Czech,
Swedish,
മലയാളം,
मराठी,
ਪੰਜਾਬੀ,
ગુજરાતી,
Portuguese,
Ukrainian
Medical Disclaimer: WikiMD is not a substitute for professional medical advice. The information on WikiMD is provided as an information resource only, may be incorrect, outdated or misleading, and is not to be used or relied on for any diagnostic or treatment purposes. Please consult your health care provider before making any healthcare decisions or for guidance about a specific medical condition. WikiMD expressly disclaims responsibility, and shall have no liability, for any damages, loss, injury, or liability whatsoever suffered as a result of your reliance on the information contained in this site. By visiting this site you agree to the foregoing terms and conditions, which may from time to time be changed or supplemented by WikiMD. If you do not agree to the foregoing terms and conditions, you should not enter or use this site. See full disclaimer.
Credits:Most images are courtesy of Wikimedia commons, and templates Wikipedia, licensed under CC BY SA or similar.
Contributors: Prab R. Tumpati, MD
