Voxergolide
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Voxergolide is a chemical compound that has been studied for its potential pharmacological effects, particularly in the context of dopamine receptor modulation. It is classified as an ergoline derivative, which is a group of compounds known for their diverse biological activities, including effects on the central nervous system.
Pharmacology[edit | edit source]
Voxergolide acts primarily as a dopamine receptor agonist, meaning it binds to and activates dopamine receptors in the brain. This action can influence various neurological and physiological processes, including mood regulation, motor control, and endocrine function. The specific receptor subtypes that voxergolide targets, as well as its affinity and efficacy at these receptors, are critical for understanding its potential therapeutic applications and side effects.
Potential Therapeutic Uses[edit | edit source]
Research into voxergolide has explored its use in treating conditions such as Parkinson's disease, where dopamine agonists can help alleviate symptoms by compensating for the loss of dopaminergic neurons. Additionally, its effects on prolactin secretion suggest potential use in disorders related to hyperprolactinemia.
Side Effects and Safety[edit | edit source]
As with other dopamine agonists, voxergolide may cause side effects such as nausea, dizziness, and orthostatic hypotension. Long-term use can lead to more serious complications, including impulse control disorders and cardiac valvulopathy, which have been observed with other ergoline derivatives.
Research and Development[edit | edit source]
Voxergolide is still under investigation, and its clinical development status may vary. Ongoing studies aim to better understand its pharmacokinetics, optimal dosing regimens, and long-term safety profile.
Also see[edit | edit source]
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Contributors: Prab R. Tumpati, MD
