ECPLA

ECPLA (Eicosapentaenoic Acid Catabolic Pathway Activator) is a protein that in humans is encoded by the ECPLA gene. This protein is involved in the catabolic pathway of eicosapentaenoic acid (EPA), a type of omega-3 fatty acid.

Function

The ECPLA protein is an activator of the catabolic pathway of eicosapentaenoic acid (EPA). EPA is an omega-3 fatty acid that is a precursor to the prostaglandin-3 (PG-3) series, leukotriene-5 series, and thromboxane-3 series. These molecules play a crucial role in inflammation, blood clotting, and vasoconstriction. By activating the catabolic pathway of EPA, ECPLA helps to regulate these processes.

Gene

The ECPLA gene is located on the chromosome 1q25.3. It spans approximately 20 kilobases and consists of 6 exons. The gene is expressed in various tissues, with the highest expression levels found in the liver, kidney, and heart.

Clinical significance

Alterations in the ECPLA gene or protein function could potentially lead to disorders related to inflammation, blood clotting, and vasoconstriction. However, more research is needed to fully understand the clinical significance of ECPLA.

See also

• Eicosapentaenoic acid
• Omega-3 fatty acid
• Prostaglandin
• Leukotriene
• Thromboxane