Bromerguride

Bromerguride is a dopamine antagonist and a serotonin antagonist that is derived from ergot. It is used as an antipsychotic.

Pharmacology

Bromerguride has a high affinity for the D2 receptor and the 5-HT2A receptor. It behaves as an antagonist at both receptors.

Chemistry

Bromerguride is a semi-synthetic alkaloid of the ergoline chemical class and is structurally related to the ergot alkaloid ergometrine.

Clinical use

Bromerguride is used as an antipsychotic in the treatment of schizophrenia. It is also used in the treatment of migraine.

Side effects

The side effects of bromerguride are similar to those of other dopamine antagonists and include extrapyramidal symptoms, dystonia, and akathisia. It can also cause nausea and vomiting.

See also

• Dopamine antagonist
• Serotonin antagonist
• Antipsychotic
• Ergot

Bromerguride Resources
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