Lysergic acid 2,4-dimethylazetidide

Lysergic acid 2,4-dimethylazetidide (commonly known as LAD) is a synthetic compound that belongs to the class of lysergamides. It is a derivative of lysergic acid, which is the main component of the psychedelic drug LSD. LAD is known for its hallucinogenic properties and has gained popularity among users seeking a similar experience to LSD.

History

LAD was first synthesized in the late 20th century by a team of chemists led by Dr. Albert Hofmann, who is also credited with the discovery of LSD. The compound was initially developed as a research chemical to study its effects on the central nervous system. However, due to its potent psychedelic properties, it soon found its way into recreational use.

Chemical Properties

LAD has a molecular formula of C16H21N3O and a molecular weight of 275.36 g/mol. It is a white crystalline powder that is soluble in organic solvents but insoluble in water. The compound undergoes rapid metabolism in the body, primarily through hepatic oxidation and conjugation, leading to the formation of various metabolites.

Pharmacology

LAD acts as a partial agonist at serotonin receptors, particularly the 5-HT2A subtype. It binds to these receptors and activates them, leading to the modulation of various neurotransmitter systems in the brain. This ultimately results in the characteristic hallucinogenic effects associated with LAD use.

Effects

The effects of LAD are similar to those of LSD, albeit with some variations. Users typically report alterations in perception, enhanced sensory experiences, and profound changes in thought patterns. The duration of the effects can vary, with the onset occurring within 30-60 minutes and the peak effects lasting for 6-10 hours. After the peak, the effects gradually subside, and users may experience an afterglow period characterized by residual psychedelic effects.

Safety and Legal Status

As a relatively new compound, the long-term effects of LAD on human health are not well understood. Limited research suggests that it may have a similar safety profile to LSD, with a low potential for acute toxicity. However, caution should be exercised when using LAD or any other hallucinogenic substance, as individual reactions can vary significantly.

The legal status of LAD varies from country to country. In some jurisdictions, it is classified as a controlled substance, while in others, it may fall into a legal gray area. It is essential to familiarize oneself with the specific laws and regulations governing its possession, distribution, and use in a particular jurisdiction.

See Also

• Lysergic Acid Diethylamide
• Psychedelic Drugs
• Hallucinogens