PRO-LAD

PRO-LAD is a psychedelic drug related to LSD. It is described by Alexander Shulgin in the book TiHKAL. PRO-LAD is a member of the lysergamide family and it is quite uncommon relative to LSD, ALD-52, ETH-LAD, and other lysergamides.

Chemistry[edit | edit source]

PRO-LAD, or 6-propyl-6-nor-lysergic acid diethylamide, is a synthetic alkaloid of the lysergamide class. It is structurally related to LSD and is named for the propyl group that is attached to the nitrogen of the polycyclic indole group of LSD.

Pharmacology[edit | edit source]

Like LSD, PRO-LAD likely acts as a 5-HT2A partial agonist. The psychedelic effects are believed to come from PRO-LAD’s efficacy at the 5-HT2A receptors. However, the role of these interactions and how they result in the psychedelic experience continues to remain elusive.

Effects[edit | edit source]

The effects of PRO-LAD are reported to be somewhat similar to those of LSD, but with a shorter duration. The effects include:

Open and closed eye visuals
Euphoria
Time distortion
Increased introspection
Conceptual thinking
Synesthesia (perceiving senses as another, such as hearing colors, or seeing sounds)
Pupil dilation

Legality[edit | edit source]

As of 2018, PRO-LAD is not controlled in the United States, but it could possibly be considered an analogue of LSD, which would make it illegal to buy, sell, or possess under the Federal Analogue Act.

References[edit | edit source]

PRO-LAD Resources
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