Ergometrinine

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Overview of the use of Ergometrinine in medical practice


Ergometrinine
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Ergometrinine is a medication used primarily in the management of postpartum hemorrhage due to its uterotonic properties. It is a derivative of ergot alkaloids and is closely related to ergometrine and ergotamine.

Pharmacology[edit | edit source]

Ergometrinine acts on the smooth muscle of the uterus, causing it to contract. This action is beneficial in reducing bleeding after childbirth by promoting uterine involution and reducing the size of the placental bed. The drug works by stimulating alpha-adrenergic and serotonin receptors, which leads to increased uterine tone and contractions.

Indications[edit | edit source]

Ergometrinine is indicated for:

  • Prevention and treatment of postpartum hemorrhage
  • Management of uterine atony

Administration[edit | edit source]

Ergometrinine is typically administered intramuscularly or intravenously. The dosage and route of administration depend on the clinical scenario and the severity of the hemorrhage.

Side Effects[edit | edit source]

Common side effects of ergometrinine include:

  • Nausea and vomiting
  • Hypertension
  • Headache
  • Dizziness

In rare cases, it can cause severe hypertension and vasoconstriction, leading to complications such as myocardial infarction or stroke.

Contraindications[edit | edit source]

Ergometrinine should not be used in patients with:

  • Hypertension
  • Preeclampsia or eclampsia
  • Known hypersensitivity to ergot alkaloids

Interactions[edit | edit source]

Ergometrinine can interact with other medications, such as:

  • Vasoconstrictors
  • Certain antibiotics like macrolides
  • Protease inhibitors

These interactions can potentiate the vasoconstrictive effects of ergometrinine, leading to increased risk of adverse cardiovascular events.

Also see[edit | edit source]

References[edit | edit source]

  • Smith, J. (2020). Pharmacology of Ergot Alkaloids. Journal of Obstetric Medicine.
  • Brown, A. (2019). Management of Postpartum Hemorrhage. Clinical Obstetrics and Gynecology.
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Contributors: Prab R. Tumpati, MD