Lysergol

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Lysergol is a naturally occurring alkaloid found in various plants, including morning glories and ergot. It is a precursor to several other alkaloids, including lysergic acid and ergotamine.

Chemistry[edit | edit source]

Lysergol is a member of the ergoline family of alkaloids. It is structurally similar to other ergolines, with a tetracyclic structure that includes a double bond in the 9,10 position. The molecule also contains a carboxamide group at the 8 position and a methyl group at the 6 position.

Biosynthesis[edit | edit source]

The biosynthesis of lysergol involves the condensation of tryptophan and dimethylallyl pyrophosphate (DMAPP) to form the intermediate chanoclavine. This is then converted to lysergol through a series of enzymatic reactions.

Pharmacology[edit | edit source]

Lysergol has been found to have vasoconstrictor properties, similar to other ergot alkaloids. It has also been found to have psychoactive effects, although these are less potent than those of lysergic acid diethylamide (LSD).

Toxicity[edit | edit source]

Like other ergot alkaloids, lysergol can be toxic in high doses. Symptoms of toxicity can include hallucinations, vasoconstriction, and gangrene.

See also[edit | edit source]


Lysergol Resources

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Contributors: Prab R. Tumpati, MD