Naxagolide
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Naxagolide is a synthetic compound that acts as a dopamine receptor agonist, primarily targeting the D2 subtype. It is used in the treatment of Parkinson's disease and other conditions characterized by dopamine deficiency. Naxagolide is known for its high affinity and selectivity for dopamine receptors, making it a valuable tool in both clinical and research settings.
Pharmacology[edit | edit source]
Naxagolide functions by mimicking the action of dopamine, a neurotransmitter that is deficient in patients with Parkinson's disease. By binding to dopamine receptors, particularly the D2 subtype, it helps to restore the dopaminergic activity in the brain, alleviating symptoms such as tremors, rigidity, and bradykinesia.
Mechanism of Action[edit | edit source]
Naxagolide binds to the D2 dopamine receptors in the central nervous system, activating them in a manner similar to endogenous dopamine. This activation leads to a series of intracellular events that result in the modulation of neuronal activity, ultimately improving motor control and reducing the symptoms of Parkinson's disease.
Pharmacokinetics[edit | edit source]
Naxagolide is well-absorbed after oral administration, with peak plasma concentrations typically reached within 1-2 hours. It is metabolized primarily in the liver and excreted via the kidneys. The half-life of naxagolide is approximately 6-8 hours, allowing for once or twice daily dosing.
Clinical Use[edit | edit source]
Naxagolide is indicated for the management of Parkinson's disease, particularly in patients who are intolerant to or have not responded adequately to other treatments such as levodopa. It may be used as monotherapy or in combination with other antiparkinsonian agents.
Side Effects[edit | edit source]
Common side effects of naxagolide include nausea, dizziness, somnolence, and orthostatic hypotension. Less common but more serious side effects can include hallucinations, impulse control disorders, and dyskinesia.
Research[edit | edit source]
Ongoing research is exploring the potential of naxagolide in treating other neurological disorders, such as Restless Legs Syndrome and certain types of dystonia.
Also see[edit | edit source]
Template:Parkinson's disease treatments Template:Dopaminergic drugs
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