Acetophenone

Acetophenone-2D-skeletal

Acetophenone is an organic compound with the formula C₆H₅C(O)CH₃. It is the simplest aromatic ketone. This colorless, viscous liquid is a precursor to useful resins and fragrances.

Properties

Acetophenone is a colorless liquid at room temperature with a sweet, pungent odor. It is slightly soluble in water, but highly soluble in most organic solvents such as alcohols, ethers, and chloroform. The compound has a melting point of 20.2 degrees Celsius and a boiling point of 202 degrees Celsius.

Synthesis

Acetophenone can be synthesized through several methods. One common method is the Friedel-Crafts acylation of benzene with acetyl chloride in the presence of an [[AlCl₃]] catalyst. Another method involves the oxidation of ethylbenzene or cumene.

Applications

Acetophenone is used primarily as an intermediate in the synthesis of resins, perfumes, and flavoring agents. It has a sweet, floral scent and is used in fragrances to impart almond, cherry, honeysuckle, jasmine, or strawberry aromas. It is also used in the preparation of certain pharmaceuticals and as a solvent for plastics and resins.

Safety

Acetophenone is considered to be moderately toxic. It can cause irritation to the skin, eyes, and respiratory tract. Ingestion or prolonged exposure can lead to more serious health effects. Proper handling and safety equipment are recommended when working with this chemical.