Benzene

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Model of a molecule of benzene. Carbon atoms are shown as black and hydrogen as white.
In 1964, the German postal service issued a stamp in commemoration of 100 years discovery of Benzene

Benzene is a colorless, flammable liquid with a sweet odor, and is an important organic chemical compound with the molecular formula C6H6. It is an aromatic hydrocarbon, which means it has a ring of carbon atoms connected by alternating single and double bonds. Benzene is widely used as a precursor to the production of various chemicals and materials, but it is also a known human carcinogen.

History[edit | edit source]

Benzene was first discovered in 1825 by English scientist Michael Faraday, who isolated it from illuminating gas. The chemical structure of benzene was later determined by German chemist Friedrich August Kekulé in 1865, who proposed the now-accepted cyclic structure with alternating single and double bonds.

Properties and structure[edit | edit source]

The various representations of benzene

Benzene is a colorless, volatile liquid with a sweet odor. It has a melting point of 5.5 °C (41.9 °F) and a boiling point of 80.1 °C (176.2 °F). Benzene is relatively insoluble in water, with a solubility of 1.79 g/L at 20 °C. It is highly flammable and can form explosive mixtures with air.

The molecular structure of benzene consists of a hexagonal ring of six carbon atoms, each bonded to a hydrogen atom, with alternating single and double carbon-carbon bonds. This unique structure gives benzene its aromatic properties and contributes to its stability and resistance to reactions.

Production[edit | edit source]

Benzene is primarily produced from petroleum sources, either through the catalytic reforming of naphtha or the steam cracking of hydrocarbons. Smaller amounts of benzene can be produced through the toluene hydrodealkylation process, in which toluene is converted to benzene by removing a methyl group. In the past, benzene was also produced from coal tar, but this method is now less common due to environmental concerns.

Uses[edit | edit source]

Benzene is a key building block for the synthesis of various chemicals and materials. Some of the primary uses for benzene include:

  • Ethylbenzene production: Benzene is used to produce ethylbenzene, which is then used to manufacture styrene, an important precursor to polystyrene plastics and synthetic rubber.
  • Cyclohexane production: Benzene is hydrogenated to form cyclohexane, which is an essential intermediate for the production of caprolactam and adipic acid, both of which are used to produce nylon fibers and plastics.
  • Cumene production: Benzene is alkylated with propylene to produce cumene, which is a precursor to phenol and acetone, used in the production of resins, adhesives, and other materials.
  • Other chemical production: Benzene is also a starting material for the production of chemicals such as aniline, chlorobenzene, and nitrobenzene, which have a wide range of industrial applications.
  • In addition to these primary uses, benzene has historically been used as a solvent for various applications, including degreasing, paint removal, and laboratory procedures. However, due to its toxic and carcinogenic properties, the use of benzene as a solvent has been largely replaced by safer alternatives.

Health effects and safety[edit | edit source]

Benzene is a known human carcinogen, and exposure to benzene has been linked to an increased risk of developing leukemia and other blood disorders. The International Agency for Research on Cancer (IARC) has classified benzene as a Group 1 carcinogen, indicating that there is sufficient evidence of its carcinogenicity in humans.

Exposure to benzene can occur through inhalation, skin contact, or ingestion. Short-term exposure to high levels of benzene can cause dizziness, headache, confusion, and unconsciousness, while long-term exposure can lead to harmful effects on the bone marrow and immune system.

To minimize the risks associated with benzene exposure, regulations have been established in many countries to limit the allowable levels of benzene in the workplace and in consumer products. Additionally, safer alternatives to benzene have been developed for use in various applications, including solvents and cleaning agents.

See also[edit | edit source]

Benzene Resources

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Contributors: Prab R. Tumpati, MD