Ciclindole

Ciclindole

Ciclindole is a synthetic antipsychotic drug of the dibenzoxazepine chemical class that was developed in the 1980s. It is primarily used in the treatment of schizophrenia and other psychotic disorders.

Chemistry

Ciclindole is a dibenzoxazepine derivative. Dibenzoxazepines are a class of compounds that contain a benzene ring fused to an oxazepine ring. The chemical structure of ciclindole is similar to that of other dibenzoxazepine antipsychotics, such as loxapine and amoxapine.

Pharmacology

Ciclindole acts as an antagonist at various neurotransmitter receptors in the brain. It has high affinity for the dopamine D2 and D3 receptors, and moderate affinity for the D1 receptor. It also has high affinity for the serotonin 5-HT2A and 5-HT2C receptors, and moderate affinity for the 5-HT1A receptor. In addition, ciclindole has affinity for the histamine H1 receptor and the adrenergic alpha1 receptor.

The antagonism of dopamine D2 receptors is thought to be responsible for the antipsychotic effects of ciclindole. The antagonism of serotonin 5-HT2A receptors may contribute to its efficacy in treating the negative symptoms of schizophrenia, such as apathy and social withdrawal.

Clinical Use

Ciclindole is used in the treatment of schizophrenia and other psychotic disorders. It may also be used off-label in the treatment of bipolar disorder and major depressive disorder.

Side Effects

Common side effects of ciclindole include drowsiness, dizziness, dry mouth, and weight gain. Less common side effects include extrapyramidal symptoms such as tardive dyskinesia, and neuroleptic malignant syndrome, a potentially life-threatening condition.

See Also

• Antipsychotic
• Dibenzoxazepine
• Schizophrenia
• Psychotic disorders