Broxaterol
Broxaterol[edit | edit source]
Broxaterol is a beta-2 adrenergic receptor agonist used primarily in the treatment of asthma and other conditions involving bronchoconstriction. It functions by relaxing the smooth muscles of the bronchi, leading to bronchodilation and improved airflow.
Pharmacology[edit | edit source]
Broxaterol acts on the beta-2 adrenergic receptors located in the bronchial smooth muscle. Activation of these receptors leads to the activation of adenylate cyclase, which increases the levels of cyclic adenosine monophosphate (cAMP). Elevated cAMP levels result in the relaxation of bronchial smooth muscle and subsequent bronchodilation.
Clinical Use[edit | edit source]
Broxaterol is indicated for the management of asthma and chronic obstructive pulmonary disease (COPD). It is administered via inhalation, which allows for direct delivery to the lungs, minimizing systemic side effects. The onset of action is rapid, making it suitable for the relief of acute bronchospasm.
Synthesis[edit | edit source]
The synthesis of Broxaterol involves a cycloaddition reaction, as depicted in the accompanying image. This process is a key step in the formation of the active compound, allowing for the precise construction of its chemical structure.
Mechanism of Action[edit | edit source]
Broxaterol's mechanism of action is primarily through the stimulation of beta-2 adrenergic receptors. This stimulation leads to a cascade of intracellular events that result in the relaxation of bronchial smooth muscle. The increased cAMP levels inhibit the phosphorylation of myosin light chain kinase, reducing muscle contraction and promoting bronchodilation.
Side Effects[edit | edit source]
Common side effects of Broxaterol include tremor, tachycardia, and nervousness. These effects are generally mild and result from the systemic absorption of the drug. In rare cases, more severe cardiovascular effects can occur, particularly in patients with pre-existing heart conditions.
Related Pages[edit | edit source]
Drug groups | Encyclopedia | Dictionary | Cancer drugs | OTC | Alternative meds | Drugs | Medications A-Z | FDA approved products | Portal:Pharmacology
Broxaterol
Broxaterol synthesis cycloaddition
Broxaterol[edit | edit source]
Broxaterol chemical structure
Broxaterol synthesis cycloaddition
Search WikiMD
Ad.Tired of being Overweight? Try W8MD's physician weight loss program.
Semaglutide (Ozempic / Wegovy and Tirzepatide (Mounjaro / Zepbound) available.
Advertise on WikiMD
|
WikiMD's Wellness Encyclopedia |
| Let Food Be Thy Medicine Medicine Thy Food - Hippocrates |
Translate this page: - East Asian
中文,
日本,
한국어,
South Asian
हिन्दी,
தமிழ்,
తెలుగు,
Urdu,
ಕನ್ನಡ,
Southeast Asian
Indonesian,
Vietnamese,
Thai,
မြန်မာဘာသာ,
বাংলা
European
español,
Deutsch,
français,
Greek,
português do Brasil,
polski,
română,
русский,
Nederlands,
norsk,
svenska,
suomi,
Italian
Middle Eastern & African
عربى,
Turkish,
Persian,
Hebrew,
Afrikaans,
isiZulu,
Kiswahili,
Other
Bulgarian,
Hungarian,
Czech,
Swedish,
മലയാളം,
मराठी,
ਪੰਜਾਬੀ,
ગુજરાતી,
Portuguese,
Ukrainian
Medical Disclaimer: WikiMD is not a substitute for professional medical advice. The information on WikiMD is provided as an information resource only, may be incorrect, outdated or misleading, and is not to be used or relied on for any diagnostic or treatment purposes. Please consult your health care provider before making any healthcare decisions or for guidance about a specific medical condition. WikiMD expressly disclaims responsibility, and shall have no liability, for any damages, loss, injury, or liability whatsoever suffered as a result of your reliance on the information contained in this site. By visiting this site you agree to the foregoing terms and conditions, which may from time to time be changed or supplemented by WikiMD. If you do not agree to the foregoing terms and conditions, you should not enter or use this site. See full disclaimer.
Credits:Most images are courtesy of Wikimedia commons, and templates, categories Wikipedia, licensed under CC BY SA or similar.
Contributors: Prab R. Tumpati, MD
