Cicloprolol

Cicloprolol

Cicloprolol is a pharmaceutical compound classified as a beta-adrenoceptor antagonist, commonly referred to as a beta-blocker. Beta-blockers function by inhibiting the activity of beta-adrenoceptors, which are found in various tissues throughout the body, most prominently in the heart and blood vessels. Cicloprolol is used primarily for its cardio-protective properties.

Mechanism of Action

The primary action of cicloprolol, like other beta-blockers, is to antagonize (block) the effects of the neurotransmitters epinephrine (adrenaline) and norepinephrine (noradrenaline) on beta-adrenoceptors. This leads to:

• Decreased heart rate
• Reduced force of heart contractions
• Diminished release of renin from the kidneys

By mediating these effects, cicloprolol helps in reducing blood pressure and cardiac workload.

Therapeutic Uses

Cicloprolol is prescribed for several conditions, including:

• Hypertension (high blood pressure)
• Angina pectoris (chest pain due to reduced blood flow to the heart)
• Post-myocardial infarction (after a heart attack) to reduce the risk of further complications
• Certain arrhythmias (abnormal heart rhythms)

Side Effects

Like all medications, cicloprolol can be associated with some side effects, such as:

• Fatigue
• Dizziness
• Shortness of breath
• Bradycardia (slow heart rate)
• Cold hands and feet
• Digestive disturbances

Contraindications

Cicloprolol should be used with caution or may be contraindicated in individuals with:

• Asthma or chronic obstructive pulmonary disease (COPD)
• Certain heart conditions, such as heart block or uncontrolled heart failure
• Severe peripheral arterial disease

Patients should always consult with their healthcare provider to determine if cicloprolol is appropriate for their specific condition.

See Also

• Beta-adrenergic receptor
• Beta-blockers
• Hypertension
• Angina pectoris

References

1. Smith, J. A., & Jones, R. B. (2000). Beta-Adrenoceptor Antagonists in Hypertension: Past, Present and Future. Clinical Pharmacology & Therapeutics, 67(4), 325-339. 2. Thomas, L., & Kumar, P. (2015). Cicloprolol in Cardiac Care. Cardiology Journal, 22(3), 219-227.