Detomidine

Detomidine is a synthetic alpha-2 adrenergic agonist that is primarily used as a sedative and analgesic in horses. It is also used in a variety of other species, including dogs, cats, and cattle. Detomidine is marketed under the trade names Dormosedan and Domosedan.

Pharmacology

Detomidine works by binding to alpha-2 adrenergic receptors in the brain, leading to a decrease in sympathetic nervous system activity, heart rate, and blood pressure. It also acts on the central nervous system to produce sedation and analgesia.

Uses

Detomidine is used in horses for sedation and to relieve pain. It is also used to facilitate procedures that require the horse to be still. It can be used in combination with other drugs to provide deeper sedation or anesthesia.

In dogs and cats, detomidine is sometimes used as a pre-anesthetic agent. It is also used in cattle for sedation during minor surgical procedures.

Side effects

The most common side effects of detomidine include bradycardia, hypotension, and respiratory depression. These effects are dose-dependent and can be reversed with an alpha-2 adrenergic antagonist.

See also

• Xylazine
• Romifidine
• Medetomidine

References

Detomidine Resources
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