Celiprolol

Celiprolol is a cardioselective beta blocker used in the treatment of hypertension and angina pectoris. It is marketed under various brand names across the globe, including Cardem, Selectol, Celipres, Cordiax, and Celicard.

Pharmacology[edit | edit source]

Celiprolol is a third-generation beta blocker. Unlike first and second-generation beta blockers, which are non-selective and cardioselective respectively, third-generation beta blockers like celiprolol possess additional vasodilatory properties. This is achieved through the activation of beta-2 adrenergic receptors, which are predominantly found in the smooth muscle lining the arteries and bronchioles.

Clinical Use[edit | edit source]

Celiprolol is primarily used in the management of hypertension and angina pectoris. It works by blocking the action of certain natural chemicals in the body, such as epinephrine, on the heart and blood vessels. This effect reduces heart rate, blood pressure, and strain on the heart.

Side Effects[edit | edit source]

Common side effects of celiprolol include fatigue, dizziness, and diarrhea. Less common side effects can include sleep disturbances, depression, and sexual dysfunction. As with all medications, the potential benefits of celiprolol should be weighed against its potential side effects.

Contraindications[edit | edit source]

Celiprolol is contraindicated in patients with a known hypersensitivity to the drug, as well as in those with severe bradycardia, hypotension, metabolic acidosis, and certain types of heart block. It should be used with caution in patients with asthma or other bronchospastic conditions due to its potential to cause bronchospasm.