Beta-2 adrenergic receptors

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beta-2 adrenergic receptor directly associates with one of its effectors, class C L-type calcium channel Ca(V)1.2. This receptor-channel complex also contains a G protein, an adenylyl cyclase, cAMP-dependent kinase, and the counterbalancing phosphatase, PP2A. This signaling complex assembly ensures specific and rapid signaling by this G protein-coupled receptor that stimulates adenylyl cyclase activity.


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Contributors: Prab R. Tumpati, MD