Intriptyline

Intriptyline is a tricyclic antidepressant (TCA) that was developed in the 1960s but was never marketed. It is similar in structure to other TCAs such as amitriptyline and imipramine.

History

Intriptyline was first synthesized in the 1960s as part of a series of TCAs. Despite showing promise in early trials, it was never brought to market. The reasons for this are unclear, but may be related to the development of newer, more effective antidepressants.

Pharmacology

Like other TCAs, intriptyline works by inhibiting the reuptake of certain neurotransmitters, specifically norepinephrine and serotonin. This increases the concentration of these neurotransmitters in the brain, which can help to alleviate symptoms of depression.

Intriptyline also has anticholinergic effects, which can lead to side effects such as dry mouth, constipation, and blurred vision. However, these effects are generally less severe than those of other TCAs.

Clinical Use

While intriptyline is not currently used in clinical practice, research into its potential uses continues. Some studies have suggested that it may be effective in treating conditions such as chronic pain, insomnia, and certain types of anxiety disorders.

Side Effects

As with other TCAs, intriptyline can cause a number of side effects. These can include dizziness, drowsiness, dry mouth, constipation, and blurred vision. In rare cases, it can also cause more serious side effects such as arrhythmias or orthostatic hypotension.

See Also

• Tricyclic antidepressant
• Amitriptyline
• Imipramine