5-HT1A receptor

5-HT1A receptor is a subtype of 5-HT receptor that binds the endogenous neurotransmitter serotonin. It is a G protein-coupled receptor (GPCR) that is coupled to Gi/Go and is located in the central and peripheral nervous system.

Function

The 5-HT1A receptor is known to be involved in several neurological and biological processes such as anxiety, appetite, sleep, sexual behavior, and thermoregulation. It is the most widespread of all the 5-HT receptors. The 5-HT1A receptors in the raphe nucleus are largely somatodendritic autoreceptors, whereas those in other areas such as the hippocampus are postsynaptic receptors.

Pharmacology

Pharmacological agents affecting the 5-HT1A receptor can be classified into agonists, partial agonists, and antagonists. Agonists increase the activity of the 5-HT1A receptor, partial agonists activate it to a lesser degree, and antagonists block the activity.

Clinical significance

Alterations in 5-HT1A receptor function and its expression are implicated in depression, anxiety disorders, schizophrenia, and Parkinson's disease. Drugs that are 5-HT1A agonists are used in the treatment of these disorders.

See also

• 5-HT receptor
• Serotonin
• G protein-coupled receptor
• Gi/Go
• Central nervous system
• Peripheral nervous system
• Anxiety
• Appetite
• Sleep
• Sexual behavior
• Thermoregulation
• Raphe nucleus
• Autoreceptor
• Hippocampus
• Pharmacology
• Agonist
• Partial agonist
• Antagonist
• Depression
• Anxiety disorders
• Schizophrenia
• Parkinson's disease