5-HT1A receptor
5-HT1A receptor is a subtype of 5-HT receptor that binds the endogenous neurotransmitter serotonin. It is a G protein-coupled receptor (GPCR) that is coupled to Gi/Go and is located in the central and peripheral nervous system.
Function[edit | edit source]
The 5-HT1A receptor is known to be involved in several neurological and biological processes such as anxiety, appetite, sleep, sexual behavior, and thermoregulation. It is the most widespread of all the 5-HT receptors. The 5-HT1A receptors in the raphe nucleus are largely somatodendritic autoreceptors, whereas those in other areas such as the hippocampus are postsynaptic receptors.
Pharmacology[edit | edit source]
Pharmacological agents affecting the 5-HT1A receptor can be classified into agonists, partial agonists, and antagonists. Agonists increase the activity of the 5-HT1A receptor, partial agonists activate it to a lesser degree, and antagonists block the activity.
Clinical significance[edit | edit source]
Alterations in 5-HT1A receptor function and its expression are implicated in depression, anxiety disorders, schizophrenia, and Parkinson's disease. Drugs that are 5-HT1A agonists are used in the treatment of these disorders.
See also[edit | edit source]
- 5-HT receptor
- Serotonin
- G protein-coupled receptor
- Gi/Go
- Central nervous system
- Peripheral nervous system
- Anxiety
- Appetite
- Sleep
- Sexual behavior
- Thermoregulation
- Raphe nucleus
- Autoreceptor
- Hippocampus
- Pharmacology
- Agonist
- Partial agonist
- Antagonist
- Depression
- Anxiety disorders
- Schizophrenia
- Parkinson's disease
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