5-HT1A receptor

5-HT1A receptor is a subtype of 5-HT receptor that binds the endogenous neurotransmitter serotonin. It is a G protein-coupled receptor (GPCR) that is coupled to Gi/Go and is located in the central and peripheral nervous system.

Function[edit | edit source]

The 5-HT1A receptor is known to be involved in several neurological and biological processes such as anxiety, appetite, sleep, sexual behavior, and thermoregulation. It is the most widespread of all the 5-HT receptors. The 5-HT1A receptors in the raphe nucleus are largely somatodendritic autoreceptors, whereas those in other areas such as the hippocampus are postsynaptic receptors.

Pharmacology[edit | edit source]

Pharmacological agents affecting the 5-HT1A receptor can be classified into agonists, partial agonists, and antagonists. Agonists increase the activity of the 5-HT1A receptor, partial agonists activate it to a lesser degree, and antagonists block the activity.

Clinical significance[edit | edit source]

Alterations in 5-HT1A receptor function and its expression are implicated in depression, anxiety disorders, schizophrenia, and Parkinson's disease. Drugs that are 5-HT1A agonists are used in the treatment of these disorders.

See also[edit | edit source]

5-HT1A receptor Resources
Need Help Finding a Doctor? Need help finding a doctor or specialist anywhere in the world? Explore our world directory. WikiMD's DocFinder can assist you in locating millions of physicians.	Medical Knowledge Access the latest research - Most recent articles Ongoing trials.