Carbinoxamine
What is Carbinoxamine?[edit | edit source]
- Carbinoxamine (Clistin, Palgic, Rondec, Rhinopront, Ryvent) is a histamine-H 1 receptor blocking agent used for symptoms of allergic rhinitis and the common cold.
What are the uses of this medicine?[edit | edit source]
Carbinoxamine (Clistin, Palgic, Rondec, Rhinopront, Ryvent) is effective for the symptomatic treatment of:
- Seasonal and perennial allergic rhinitis.
- Vasomotor rhinitis.
- Allergic conjunctivitis due to inhalant allergens and foods.
- Mild, uncomplicated allergic skin manifestations of urticaria and angioedema.
- Dermatographism
- As therapy for anaphylactic reactions adjunctive to epinephrine.
- Amelioration of the severity of allergic reactions to blood or plasma.
How does this medicine work?[edit | edit source]
- Carbinoxamine maleate, an ethanolamine derivative, is an antihistamine with anticholinergic (drying) and sedative properties.
- Carbinoxamine appears to compete with histamine (type H1) for receptor sites on effector cells in the gastrointestinal tract, blood vessels and respiratory tract.
Who Should Not Use this medicine ?[edit | edit source]
This medicine cannot be used:
- in children younger than 2 years of age.
- in nursing mothers.
- in patients who are hypersensitive to the drug or on monoamine oxidase inhibitor therapy.
What drug interactions can this medicine cause?[edit | edit source]
- Tell your healthcare provider about all the medicines you take, including prescription and over-the-counter medicines, vitamins, and herbal supplements.
Be sure to mention any of the following:
- Monoamine oxidase inhibitors
- alcohol and other CNS depressants (hypnotics sedatives, tranquilizers, etc.).
Is this medicine FDA approved?[edit | edit source]
- It was patented in 1947 and came into medical use in 1953.
- It was first launched in the United States by the McNeil Corporation under the brand name Clistin.
How should this medicine be used?[edit | edit source]
- Carbinoxamine maleate dosage should be based on the severity of the condition and the response of the patient.
Recommended dosage: Tablets: Usual Adult Dosage:
- 1 or 2 tablets (4 to 8 mg) 3 to 4 times daily.
Usual Child’s Dosage:
- Six to eleven years – 1/2 to 1 tablet (2 to 4 mg) 3 to 4 times daily.
Oral Solution:
Usual Adult Dosage:
- 1 or 2 teaspoonfuls (4 to 8 mg) 3 to 4 times daily.
Usual Child's Dosage (approximately 0.2 to 0.4 mg/kg/day, divided into 3 to 4 doses):
- Six to eleven years - ½ to 1 teaspoonful (2 to 4 mg) 3 to 4 times daily.
- Dosing for children 2 to 5 years of age should be based on weight whenever possible.
- The usual dosage for children 2 to 5 years of age is approximately 0.2 to 0.4 mg/kg/day, divided into 3 to 4 daily doses.
- In general, this corresponds to a dose of 1/4 to 1/2 teaspoonful (1 to 2 mg) 3 to 4 times daily.
Administration:
- Carbinoxamine maleate should be taken on an empty stomach with water.
- Take this medication by mouth as directed by your doctor.
What are the dosage forms and brand names of this medicine?[edit | edit source]
This medicine is available in fallowing doasage form:
- As Carbinoxamine Maleate Tablets
- Carbinoxamine Maleate Oral Solution
This medicine is available in fallowing brand namesː Clistin, Palgic, Rondec, Rhinopront, Ryvent
What side effects can this medication cause?[edit | edit source]
The most common side effects of this medicine include:
- Sedation
- sleepiness
- dizziness
- disturbed coordination
- Epigastric distress
- Thickening of bronchial secretions
- Antihistamines can worsen urinary retention and glaucoma.
Less common side effects, may include:
- Urticaria, drug rash, anaphylactic shock, photosensitivity, excessive perspiration, chills, dryness of mouth, nose and throat
- Hypotension, headache, palpitations, tachycardia, extrasystoles
- Hemolytic anemia, thrombocytopenia, agranulocytosis
- fatigue, confusion, restlessness, excitation, nervousness, tremor, irritability, insomnia, euphoria, paresthesia, blurred vision, diplopia, vertigo, tinnitus, acute labyrinthitis, hysteria, neuritis, convulsions
- anorexia, nausea, vomiting, diarrhea, constipation
- Urinary frequency, difficult urination, urinary retention, early menses
- tightness of chest and wheezing, nasal stuffiness
What special precautions should I follow?[edit | edit source]
- Deaths have been reported in children less than 2 years of age who were taking antihistamines, including carbinoxamine-containing drug products, therefore, carbinoxamine maleate is contraindicated in children younger than 2 years of age.
- carbinoxamine maleate should be used with caution in patients with: increased intraocular pressure, hyperthyroidism, cardiovascular disease, hypertension.
- Antihistamines such as carbinoxamine maleate should not be used to treat lower respiratory tract symptoms, including asthma.
- Carbinoxamine maleate may cause drowsiness; alcohol, sedatives, and tranquilizers may increase the drowsiness effect. Avoid alcoholic beverages while taking this product.
- Do not take this product if you are taking sedatives or tranquilizers, without first consulting your doctor.
- Use caution when driving a motor vehicle or operating machinery.
- Because of the higher risk of antihistamines for infants generally and for newborns and prematures in particular, use of carbinoxamine maleate is contraindicated in nursing mothers.
- Carbinoxamine has not been linked to instances of clinically apparent acute liver injury.
What to do in case of emergency/overdose?[edit | edit source]
Symptoms of overdosage may include:
- Especially in infants and children, antihistamine overdosage may cause hallucinations, convulsions, or death.
Management of overdosage:
- In case of overdose, call the poison control helpline of your country. In the United States, call 1-800-222-1222.
- Overdose related information is also available online at poisonhelp.org/help.
- In the event that the victim has collapsed, had a seizure, has trouble breathing, or can't be awakened, immediately call emergency services. In the United States, call 911.
- The treatment of overdosage with carbinoxamine maleate is essentially symptomatic and supportive.
- Vital signs (including respiration, pulse, blood pressure, and temperature) and EKG should be monitored.
- Induction of vomiting is not recommended.
- Activated charcoal should be given and gastric lavage should be considered after ingestion of a potentially life-threatening amount of drug.
- In the presence of severe anticholinergic effects, physostigmine may be useful.
- Vasopressors may be used to treat hypotensio
Can this medicine be used in pregnancy?[edit | edit source]
- Pregnancy Category C.
- It is also not known whether carbinoxamine maleate can cause fetal harm when administered to a pregnant woman or can affect reproductive capacity.
- Carbinoxamine maleate should be given to a pregnant woman only if clearly needed.
Can this medicine be used in children?[edit | edit source]
- Carbinoxamine maleate is contraindicated in children younger than 2 years of age.
What are the active and inactive ingredients in this medicine?[edit | edit source]
Active ingredients:
- CARBINOXAMINE MALEATE
Inactive ingredients:
- ANHYDROUS LACTOSE
- CELLULOSE, MICROCRYSTALLINE
- MAGNESIUM STEARATE
- SODIUM STARCH GLYCOLATE TYPE A POTATO
Who manufactures and distributes this medicine?[edit | edit source]
Distributed by:
- Breckenridge Pharmaceutical, Inc.
- Berlin, CT
Manufactured by:
- MIKART, LLC
- Atlanta, GA
What should I know about storage and disposal of this medication?[edit | edit source]
- Store at 20°C to 25°C (68°F to 77°F).
- Dispense in a tight, light-resistant container with a child-resistant closure as defined in the official compendium.
First Generation Antihistamines
- Brompheniramine
- Carbinoxamine
- Chlorcyclizine
- Chlorpheniramine
- Clemastine
- Cyclizine
- Cyproheptadine
- Dexbrompheniramine
- Dexchlorpheniramine
- Dimenhydrinate
- Diphenhydramine
- Doxylamine
- Hydroxyzine
- Meclizine
- Phenyltoloxamine
- Promethazine
- Triprolidine
Second Generation Antihistamines
Carbinoxamine Resources | ||
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