Otilonium bromide

Otilonium Bromide is a quaternary ammonium compound used in the treatment of Irritable Bowel Syndrome (IBS) and other gastrointestinal disorders. It is a spasmolytic agent that acts by regulating the motility of the gastrointestinal tract, reducing the intensity and frequency of spasms.

Pharmacology

Otilonium bromide is a muscle relaxant that works by blocking the activity of certain types of muscle fibers in the gut. This helps to reduce the spasms that can cause pain and discomfort in conditions like IBS. It is a non-selective antagonist of muscarinic receptors, calcium channels, and tachykinin NK2 receptors.

Clinical Use

Otilonium bromide is used primarily in the treatment of IBS, a common disorder that affects the large intestine. Symptoms of IBS can include cramping, abdominal pain, bloating, gas, and diarrhea or constipation. Otilonium bromide can help to alleviate these symptoms by reducing the frequency and intensity of intestinal spasms.

In addition to IBS, otilonium bromide may also be used to treat other gastrointestinal disorders that are characterized by abnormal gut motility, such as chronic constipation and functional dyspepsia.

Side Effects

Like all medications, otilonium bromide can cause side effects. The most common side effects include dry mouth, blurred vision, and constipation. Less common side effects can include dizziness, headache, and urinary retention. In rare cases, otilonium bromide can cause an allergic reaction.

Dosage

The typical dosage of otilonium bromide for adults is 40 mg taken three times a day. The medication is usually taken before meals. The duration of treatment can vary depending on the severity of symptoms and the individual patient's response to therapy.

See Also

• Irritable Bowel Syndrome
• Muscarinic antagonist
• Calcium channel blocker
• Tachykinin NK2 receptor