Hyoscine butylbromide
An antispasmodic medication used to treat crampy abdominal pain
| Hyoscine butylbromide | |
|---|---|
| File:Hyoscine butylbromide.svg | |
| INN | |
| Drug class | |
| Routes of administration | Oral, intravenous, intramuscular, rectal |
| Pregnancy category | |
| Bioavailability | Low |
| Metabolism | Hepatic |
| Elimination half-life | 5 hours |
| Excretion | Renal |
| Legal status | |
| CAS Number | |
| PubChem | |
| DrugBank | |
| ChemSpider | |
| KEGG | |
Hyoscine butylbromide, also known as scopolamine butylbromide, is a medication used to treat abdominal pain associated with cramps and spasms of the gastrointestinal tract. It is commonly marketed under the brand name Buscopan.
Pharmacology[edit | edit source]
Hyoscine butylbromide is a quaternary ammonium compound derived from the plant Duboisia. It acts as an anticholinergic agent, specifically targeting the muscarinic acetylcholine receptors in the smooth muscle of the gastrointestinal tract. By inhibiting these receptors, hyoscine butylbromide reduces the muscle contractions that cause spasms and cramps.
Uses[edit | edit source]
Hyoscine butylbromide is primarily used to relieve abdominal pain and discomfort associated with cramps and spasms in the stomach and intestines. It is also used in the management of irritable bowel syndrome (IBS) and other conditions that involve gastrointestinal motility disorders.
Administration[edit | edit source]
Hyoscine butylbromide can be administered via several routes, including oral, intravenous, intramuscular, and rectal. The choice of administration depends on the severity of the symptoms and the clinical setting. For rapid relief, intravenous or intramuscular administration is preferred.
Side Effects[edit | edit source]
Common side effects of hyoscine butylbromide include dry mouth, dizziness, and blurred vision. These effects are due to its anticholinergic properties. Less common side effects include urinary retention, constipation, and tachycardia.
Contraindications[edit | edit source]
Hyoscine butylbromide is contraindicated in individuals with myasthenia gravis, megacolon, and narrow-angle glaucoma. Caution is advised in patients with prostatic hypertrophy and tachyarrhythmias.
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