Benzydamine

Benzydamine synthesis

Benzydamine synthesis 2

Benzydamine (IUPAC name: 3-(1-benzylindazol-3-yl)oxy-N,N-dimethylaniline), also known by its brand name Tantum Verde among others, is a nonsteroidal anti-inflammatory drug (NSAID) with analgesic and local anesthetic properties. Primarily used for its pain-relieving and anti-inflammatory effects in conditions such as pharyngitis, it is also effective in the treatment of various inflammatory conditions of the mouth and throat.

Pharmacology

Benzydamine works by inhibiting the production of prostaglandins, substances in the body that mediate inflammation and pain. Unlike other NSAIDs, benzydamine exhibits local anaesthetic and analgesic properties that are not solely attributable to its anti-inflammatory effects. It is believed to also act through inhibition of the synthesis of pro-inflammatory cytokines like tumor necrosis factor alpha (TNFα) and interleukin-1β (IL-1β).

Indications

Benzydamine is indicated for the symptomatic relief of pain in conditions such as musculoskeletal pain, postoperative pain, dysmenorrhea, and specifically for inflammatory conditions of the mouth and throat, such as tonsillitis, pharyngitis, and stomatitis. It is available in various forms, including oral rinse, spray, gel, and cream, allowing for versatile application depending on the condition being treated.

Side Effects

The side effects of benzydamine are generally mild and may include nausea, vomiting, and oral numbness or burning sensation when used in the mouth or throat. Allergic reactions are rare but can occur, manifesting as rash, itching, or more severe hypersensitivity reactions.

Contraindications

Benzydamine should be used with caution in patients with a history of hypersensitivity to NSAIDs. It is contraindicated in individuals with known hypersensitivity to benzydamine or any of its excipients.

Dosage and Administration

The dosage of benzydamine varies depending on the formulation and the condition being treated. For mouth and throat conditions, it is typically used as a 0.15% oral rinse or spray, applied three to six times a day. The specific dosage and duration of treatment should be based on the severity of the condition and the response to treatment.

Pharmacokinetics

Benzydamine is rapidly absorbed when applied locally in the mouth or throat, with systemic absorption being minimal. The drug is extensively metabolized in the liver and excreted primarily in the urine.

History

Benzydamine was first synthesized in the 1960s and has since been used in various countries for the treatment of pain and inflammation associated with a wide range of conditions. Its unique mechanism of action and efficacy in treating inflammatory conditions of the mouth and throat have made it a valuable tool in pain management and anti-inflammatory therapy.

See Also

• Nonsteroidal anti-inflammatory drug
• Analgesic
• Local anesthetic
• Prostaglandin
• Inflammation