Quinupramine

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Tricyclic antidepressant

Quinupramine

Quinupramine
Chemical structure of Quinupramine


Trade names Kinupril


Chemical nomenclature
IUPAC name 3-(11-azatricyclo[7.3.1.0^{2,7}]trideca-2(7),3,5,10,12-pentaen-11-yl)-N,N-dimethylpropan-1-amine



Routes Oral



Metabolism Hepatic


Excretion Renal


Identifiers
CAS Number 24881-13-6
PubChem 3047790
DrugBank DB08998
ChemSpider 2310105
UNII 0T493YFU8O
KEGG D07356
ChEMBL 2104664
Chemical data


Chemical formula C20H26N2


SMILES CN(C)CCCN1C2=CC=CC=C2C3=CC=CC=C31
InChI 1S/C20H26N2/c1-22(2)15-9-16-21-19-13-7-4-10-17(19)18-11-5-8-14-20(18)21/h4-5,7-8,10,13-14H,9,11-12,15-16H2,1-2H3
InChIKey ZQFJQKLOKISXDH-UHFFFAOYSA-N


Quinupramine is a tricyclic antidepressant (TCA) that is used in the treatment of depression. It is known for its unique chemical structure and pharmacological properties that distinguish it from other TCAs.

Chemical Structure[edit]

Chemical structure of Quinupramine

Quinupramine is characterized by its tricyclic structure, which consists of three interconnected rings. The chemical formula for quinupramine is C20H26N2. This structure is responsible for its pharmacological activity as a TCA.

Pharmacology[edit]

Quinupramine functions primarily by inhibiting the reuptake of neurotransmitters such as serotonin and norepinephrine, thereby increasing their levels in the synaptic cleft and enhancing neurotransmission. This mechanism is similar to other TCAs, which are known to improve mood and alleviate symptoms of depression.

Clinical Use[edit]

Quinupramine is prescribed for the treatment of major depressive disorder. It is administered orally and is metabolized in the liver. The drug is excreted through the kidneys.

Side Effects[edit]

As with other tricyclic antidepressants, quinupramine can cause a range of side effects. Common side effects include dry mouth, constipation, urinary retention, and blurred vision. These effects are primarily due to its anticholinergic properties.

Related Pages[edit]

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