ABT-239
ABT-239 is a drug that was developed by Abbott Laboratories. It is a potent and selective antagonist of the histamine H3 receptor, and has nootropic and neuroprotective effects in animal studies. ABT-239 has been researched for potential use in the treatment of Alzheimer's disease and schizophrenia, but development was discontinued due to the risk of QTc prolongation.
Pharmacology[edit | edit source]
ABT-239 is a potent and selective antagonist of the histamine H3 receptor. This receptor is found in the central nervous system and is involved in the regulation of neurotransmitter release. By blocking this receptor, ABT-239 increases the release of acetylcholine and dopamine, neurotransmitters that are involved in cognition and mood.
Clinical trials[edit | edit source]
ABT-239 has been tested in phase I and II clinical trials for the treatment of Alzheimer's disease and schizophrenia. However, development was discontinued due to the risk of QTc prolongation, a condition that can lead to life-threatening arrhythmias.
Potential therapeutic uses[edit | edit source]
Despite the discontinuation of its development, ABT-239 has been the subject of research due to its potential therapeutic uses. Its ability to increase the release of acetylcholine and dopamine makes it a potential treatment for cognitive disorders such as Alzheimer's disease and attention deficit hyperactivity disorder (ADHD). Furthermore, its potential to modulate mood suggests it could be useful in the treatment of depression and anxiety disorders.
See also[edit | edit source]
| ABT-239 Resources | |
|---|---|
|
 |
Search WikiMD
Ad.Tired of being Overweight? Try W8MD's physician weight loss program.
Semaglutide (Ozempic / Wegovy and Tirzepatide (Mounjaro / Zepbound) available.
Advertise on WikiMD
|
WikiMD's Wellness Encyclopedia |
| Let Food Be Thy Medicine Medicine Thy Food - Hippocrates |
Translate this page: - East Asian
中文,
日本,
한국어,
South Asian
हिन्दी,
தமிழ்,
తెలుగు,
Urdu,
ಕನ್ನಡ,
Southeast Asian
Indonesian,
Vietnamese,
Thai,
မြန်မာဘာသာ,
বাংলা
European
español,
Deutsch,
français,
Greek,
português do Brasil,
polski,
română,
русский,
Nederlands,
norsk,
svenska,
suomi,
Italian
Middle Eastern & African
عربى,
Turkish,
Persian,
Hebrew,
Afrikaans,
isiZulu,
Kiswahili,
Other
Bulgarian,
Hungarian,
Czech,
Swedish,
മലയാളം,
मराठी,
ਪੰਜਾਬੀ,
ગુજરાતી,
Portuguese,
Ukrainian
Medical Disclaimer: WikiMD is not a substitute for professional medical advice. The information on WikiMD is provided as an information resource only, may be incorrect, outdated or misleading, and is not to be used or relied on for any diagnostic or treatment purposes. Please consult your health care provider before making any healthcare decisions or for guidance about a specific medical condition. WikiMD expressly disclaims responsibility, and shall have no liability, for any damages, loss, injury, or liability whatsoever suffered as a result of your reliance on the information contained in this site. By visiting this site you agree to the foregoing terms and conditions, which may from time to time be changed or supplemented by WikiMD. If you do not agree to the foregoing terms and conditions, you should not enter or use this site. See full disclaimer.
Credits:Most images are courtesy of Wikimedia commons, and templates Wikipedia, licensed under CC BY SA or similar.
Contributors: Prab R. Tumpati, MD
