Oxomemazine

Oxomemazine

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Chemical structure of Oxomemazine

Oxomemazine is a phenothiazine derivative with antihistamine and sedative properties. It is commonly used in the treatment of allergic reactions and coughs due to its ability to block histamine receptors and provide a calming effect.

Pharmacology

Oxomemazine acts primarily as an H1 receptor antagonist, which means it blocks the action of histamine at the H1 receptor sites. This action helps reduce symptoms associated with allergic reactions, such as itching, sneezing, and runny nose.

Mechanism of Action

The drug works by inhibiting the binding of histamine to its receptors, thereby preventing the cascade of allergic symptoms. Additionally, oxomemazine has a mild anticholinergic effect, which contributes to its sedative properties.

Clinical Uses

Oxomemazine is primarily used for its antihistaminic effects in the management of allergic rhinitis, urticaria, and other allergic conditions. It is also used as a cough suppressant due to its sedative effects, which can help reduce the frequency and intensity of coughing.

Side Effects

Common side effects of oxomemazine include drowsiness, dry mouth, and dizziness. Due to its sedative properties, it may impair the ability to perform tasks that require mental alertness, such as driving.

Contraindications

Oxomemazine should not be used in individuals with a known hypersensitivity to phenothiazines or any of its components. Caution is advised in patients with glaucoma, prostatic hypertrophy, or urinary retention.

Related Pages

• Antihistamine
• Phenothiazine
• Allergic rhinitis
• Cough suppressant