Rupatadine

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Rupatadine


Rupatadine is a second-generation antihistamine and Paf antagonist used to treat allergies. It is marketed under the brand name Rupafin by J. Uriach y Compañía, S.A. in several European countries, including Spain and the United Kingdom.

Pharmacology[edit]

Rupatadine is a selective, non-sedating antagonist at H1 receptors. It also inhibits platelet-activating factor (PAF) and has been shown to inhibit the release of histamine, tryptase, and other cytokines, possibly via its additional actions on mast cells.

Clinical use[edit]

Rupatadine is used for the treatment of allergic rhinitis and chronic idiopathic urticaria. It is usually administered orally in the form of a tablet, but a solution for oral administration is also available. The recommended dose for adults and children over 12 years of age is 10 mg once daily.

Side effects[edit]

The most common side effects of rupatadine include somnolence, headache, and fatigue. Less common side effects can include dry mouth, nausea, and dizziness. As with all medicines, if any side effects persist or worsen, medical advice should be sought.

Interactions[edit]

Rupatadine may interact with other medicines, including those that also have antihistamine properties. It is therefore important to inform the prescribing doctor of all medicines being taken, including over-the-counter medicines and herbal remedies.

See also[edit]

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