Piroheptine
An anticholinergic drug used in the treatment of Parkinson's disease
| Piroheptine | |
|---|---|
| |
| INN | |
| Drug class | |
| Routes of administration | |
| Pregnancy category | |
| Bioavailability | |
| Metabolism | |
| Elimination half-life | |
| Excretion | |
| Legal status | |
| CAS Number | |
| PubChem | |
| DrugBank | |
| ChemSpider | |
| KEGG | |
Piroheptine is a pharmacological agent classified as an anticholinergic drug. It is primarily used in the management of Parkinson's disease, a neurodegenerative disorder characterized by tremor, rigidity, and bradykinesia.
Mechanism of Action[edit | edit source]
Piroheptine functions by inhibiting the action of acetylcholine, a neurotransmitter involved in the regulation of motor control. By blocking acetylcholine receptors, piroheptine helps to restore the balance between acetylcholine and dopamine in the central nervous system, which is often disrupted in Parkinson's disease.
Pharmacokinetics[edit | edit source]
Piroheptine is administered orally and is absorbed through the gastrointestinal tract. It undergoes hepatic metabolism and is excreted primarily through the renal system. The drug has a moderate half-life, allowing for dosing multiple times a day to maintain therapeutic levels.
Clinical Use[edit | edit source]
Piroheptine is indicated for the treatment of Parkinsonian syndromes, including idiopathic Parkinson's disease and drug-induced parkinsonism. It is often used in combination with other antiparkinsonian agents such as levodopa to enhance therapeutic outcomes.
Side Effects[edit | edit source]
Common side effects of piroheptine include dry mouth, constipation, urinary retention, and blurred vision. These effects are typical of anticholinergic drugs due to their action on the parasympathetic nervous system.
Contraindications[edit | edit source]
Piroheptine is contraindicated in patients with glaucoma, prostatic hypertrophy, and obstructive gastrointestinal disorders. Caution is advised in elderly patients due to the increased risk of cognitive impairment.
Related pages[edit | edit source]
Piroheptine
Search WikiMD
Ad.Tired of being Overweight? Try W8MD's physician weight loss program.
Semaglutide (Ozempic / Wegovy and Tirzepatide (Mounjaro / Zepbound) available.
Advertise on WikiMD
|
WikiMD's Wellness Encyclopedia |
| Let Food Be Thy Medicine Medicine Thy Food - Hippocrates |
Translate this page: - East Asian
中文,
日本,
한국어,
South Asian
हिन्दी,
தமிழ்,
తెలుగు,
Urdu,
ಕನ್ನಡ,
Southeast Asian
Indonesian,
Vietnamese,
Thai,
မြန်မာဘာသာ,
বাংলা
European
español,
Deutsch,
français,
Greek,
português do Brasil,
polski,
română,
русский,
Nederlands,
norsk,
svenska,
suomi,
Italian
Middle Eastern & African
عربى,
Turkish,
Persian,
Hebrew,
Afrikaans,
isiZulu,
Kiswahili,
Other
Bulgarian,
Hungarian,
Czech,
Swedish,
മലയാളം,
मराठी,
ਪੰਜਾਬੀ,
ગુજરાતી,
Portuguese,
Ukrainian
Medical Disclaimer: WikiMD is not a substitute for professional medical advice. The information on WikiMD is provided as an information resource only, may be incorrect, outdated or misleading, and is not to be used or relied on for any diagnostic or treatment purposes. Please consult your health care provider before making any healthcare decisions or for guidance about a specific medical condition. WikiMD expressly disclaims responsibility, and shall have no liability, for any damages, loss, injury, or liability whatsoever suffered as a result of your reliance on the information contained in this site. By visiting this site you agree to the foregoing terms and conditions, which may from time to time be changed or supplemented by WikiMD. If you do not agree to the foregoing terms and conditions, you should not enter or use this site. See full disclaimer.
Credits:Most images are courtesy of Wikimedia commons, and templates, categories Wikipedia, licensed under CC BY SA or similar.
Contributors: Prab R. Tumpati, MD
